P
Peter Hegemann
Researcher at Humboldt University of Berlin
Publications - 313
Citations - 28212
Peter Hegemann is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Channelrhodopsin & Chlamydomonas reinhardtii. The author has an hindex of 72, co-authored 286 publications receiving 24667 citations. Previous affiliations of Peter Hegemann include Free University of Berlin & University of Regensburg.
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Journal ArticleDOI
Channelrhodopsin-2, a directly light-gated cation-selective membrane channel.
Georg Nagel,Tanjef Szellas,Wolfram Huhn,Suneel Kateriya,Nona Adeishvili,Peter Berthold,Doris Ollig,Peter Hegemann,Ernst Bamberg +8 more
TL;DR: It is demonstrated by functional expression, both in oocytes of Xenopus laevis and mammalian cells, that ChR2 is a directly light-switched cation-selective ion channel, and may be used to depolarize small or large cells, simply by illumination.
Journal ArticleDOI
Neocortical excitation/inhibition balance in information processing and social dysfunction
Ofer Yizhar,Ofer Yizhar,Lief E. Fenno,Matthias Prigge,Franziska Schneider,Thomas J. Davidson,Daniel J. O’Shea,Vikaas S. Sohal,Vikaas S. Sohal,Inbal Goshen,Joel Finkelstein,Jeanne T. Paz,Katja Stehfest,Roman Fudim,Charu Ramakrishnan,John R. Huguenard,Peter Hegemann,Karl Deisseroth +17 more
TL;DR: In this article, the authors design and use several optogenetic tools to causally investigate the cellular E/I balance hypothesis in freely moving mammals, and explore the associated circuit physiology.
Neocortical excitation/inhibition balance in information processing and social
Lief E. Fenno,Matthias Prigge,Franziska Schneider,Thomas J. Davidson,Vikaas S. Sohal,Inbal Goshen,Joel Finkelstein,Jeanne T. Paz,Katja Stehfest,Roman Fudim,Charu Ramakrishnan,John R. Huguenard,Peter Hegemann,Karl Deisseroth +13 more
TL;DR: Elevation, but not reduction, of cellular E/I balance within the mouse medial prefrontal cortex was found to elicit a profound impairment in cellular information processing, associated with specific behavioural impairments and increased high-frequency power in the 30–80 Hz range, which have both been observed in clinical conditions in humans.
Journal ArticleDOI
Channelrhodopsin-1: a light-gated proton channel in green algae.
Georg Nagel,Doris Ollig,Markus Fuhrmann,Suneel Kateriya,Anna Maria Musti,Ernst Bamberg,Peter Hegemann +6 more
TL;DR: A complementary DNA sequence in the green alga Chlamydomonas reinhardtiithat encodes a microbial opsin-related protein, which is suggested to be Channelopsin-1, which shows homology to the light-activated proton pump bacteriorhodopsin.
Journal ArticleDOI
Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.
Oliver P. Ernst,David T. Lodowski,Marcus Elstner,Peter Hegemann,Leonid S. Brown,Hideki Kandori +5 more
TL;DR: Rhodopsins found in Eukaryotes, Bacteria, and Archaea consist of opsin apoproteins and a covalently linked retinal which is employed to absorb photons for energy conversion or the initiation of intra- or intercellular signaling.