P
Peter J. Lewis
Researcher at University of Newcastle
Publications - 91
Citations - 4288
Peter J. Lewis is an academic researcher from University of Newcastle. The author has contributed to research in topics: RNA polymerase & Bacillus subtilis. The author has an hindex of 31, co-authored 87 publications receiving 3883 citations. Previous affiliations of Peter J. Lewis include Newcastle University & University of Sydney.
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Journal ArticleDOI
Condition-Dependent Transcriptome Reveals High-Level Regulatory Architecture in Bacillus subtilis
Pierre Nicolas,Ulrike Mäder,Etienne Dervyn,Tatiana Rochat,Aurélie Leduc,Nathalie Pigeonneau,Elena Bidnenko,Elodie Marchadier,Mark Hoebeke,Stéphane Aymerich,Dörte Becher,Paola Bisicchia,Eric Botella,Olivier Delumeau,Geoff Doherty,Emma L. Denham,Mark J. Fogg,Vincent Fromion,Anne Goelzer,Annette Hansen,Elisabeth Härtig,Colin R. Harwood,Georg Homuth,Hanne Østergaard Jarmer,Matthieu Jules,Edda Klipp,Ludovic Le Chat,François Lecointe,Peter J. Lewis,Wolfram Liebermeister,Anika March,Ruben A. T. Mars,Priyanka Nannapaneni,David Noone,Susanne Pohl,Bernd Rinn,Frank Rügheimer,Praveen K. Sappa,Franck Samson,Marc Schaffer,Benno Schwikowski,Leif Steil,Jörg Stülke,Thomas Wiegert,Kevin M. Devine,Anthony J. Wilkinson,Jan Maarten van Dijl,Michael Hecker,Uwe Völker,Philippe Bessières,Philippe Noirot +50 more
TL;DR: The transcriptomes of Bacillus subtilis exposed to a wide range of environmental and nutritional conditions that the organism might encounter in nature are reported, offering an initial understanding of why certain regulatory strategies may be favored during evolution of dynamic control systems.
Journal ArticleDOI
Global Network Reorganization During Dynamic Adaptations of Bacillus subtilis Metabolism
Joerg Martin Buescher,Wolfram Liebermeister,Matthieu Jules,Markus Uhr,Jan Muntel,Eric Botella,Bernd Hessling,Roelco J. Kleijn,Ludovic Le Chat,François Lecointe,Ulrike Mäder,Pierre Nicolas,Sjouke Piersma,Frank Rügheimer,Dörte Becher,Philippe Bessières,Elena Bidnenko,Emma L. Denham,Etienne Dervyn,Kevin M. Devine,Geoff Doherty,Samuel Drulhe,Liza Felicori,Mark J. Fogg,Anne Goelzer,Annette Hansen,Colin R. Harwood,Michael Hecker,Sebastian Hubner,Claus Hultschig,Hanne Østergaard Jarmer,Edda Klipp,Aurélie Leduc,Peter J. Lewis,F. Molina,Philippe Noirot,Sabine Peres,Nathalie Pigeonneau,Susanne Pohl,Simon Rasmussen,Bernd Rinn,Marc Schaffer,Julian Schnidder,Benno Schwikowski,Jan Maarten van Dijl,Patrick Veiga,Sean Walsh,Anthony J. Wilkinson,Jörg Stelling,Stéphane Aymerich,Uwe Sauer +50 more
TL;DR: The responses of a bacterium to changing nutritional conditions are explored and an initial understanding of why certain regulatory strategies may be favored during evolution of dynamic control systems is offered.
Journal ArticleDOI
GFP vectors for controlled expression and dual labelling of protein fusions in Bacillus subtilis
Peter J. Lewis,Adele L. Marston +1 more
TL;DR: It is shown that fusions to GFPmut1 and GFPuv can be co-localized within the cell by virtue of their different excitation spectra, which allows downstream genes to be placed under inducible control.
Journal ArticleDOI
Compartmentalization of transcription and translation in Bacillus subtilis.
TL;DR: It is found that, even in the absence of a nuclear membrane, transcription and translation occur predominantly in separate functional domains, and RNAP resides principally within the nucleoid.
Journal ArticleDOI
Direct evidence for active segregation of oriC regions of the Bacillus subtilis chromosome and co‐localization with the Spo0J partitioning protein
Peter J. Lewis,Jeffery Errington +1 more
TL;DR: Methods for labelling regions of the Bacillus subtilis chromosome with the nucleotide analogue 5‐bromodeoxyuridine (BrdU) and for subcellular visualization of the labelled DNA provide further support for the notion that bacterial cells use an active mitotic‐like mechanism to segregate their chromosomes.