P
Peter J. Mohler
Researcher at Ohio State University
Publications - 281
Citations - 15159
Peter J. Mohler is an academic researcher from Ohio State University. The author has contributed to research in topics: Ankyrin & Ca2+/calmodulin-dependent protein kinase. The author has an hindex of 62, co-authored 263 publications receiving 13145 citations. Previous affiliations of Peter J. Mohler include Duke University & Roy J. and Lucille A. Carver College of Medicine.
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Journal ArticleDOI
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation
Jeffrey R. Erickson,Mei Ling A. Joiner,Xiaoqun Guan,William Kutschke,Jinying Yang,Carmine V. Oddis,Ryan K. Bartlett,John S. Lowe,Susan E. O'Donnell,Nukhet Aykin-Burns,Matthew C. Zimmerman,Kathy Zimmerman,Amy-Joan L. Ham,Robert M. Weiss,Douglas R. Spitz,Madeline A. Shea,Roger J. Colbran,Peter J. Mohler,Mark E. Anderson +18 more
TL;DR: It is shown that oxidation of paired regulatory domain methionine residues sustains CaMKII activity in the absence of Ca2+/CaM and highlights the critical importance of oxidation-dependent CaMK II activation to AngII and ischemic myocardial apoptosis.
Journal ArticleDOI
Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death
Peter J. Mohler,Jean-Jacques Schott,Anthony O. Gramolini,Keith W. Dilly,Silvia Guatimosim,William H. duBell,Long-Sheng Song,Karine Haurogné,Florence Kyndt,Mervat E. Ali,Terry B. Rogers,W. J. Lederer,Denis Escande,Hervé Le Marec,Vann Bennett,Vann Bennett +15 more
TL;DR: It is reported that a loss-of-function (E1425G) mutation in ankyrin-B, a member of a family of versatile membrane adapters, causes dominantly inherited type 4 long-QT cardiac arrhythmia in humans.
Journal ArticleDOI
FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death
Xander H.T. Wehrens,Stephan E. Lehnart,Fannie Huang,John A. Vest,Steven Reiken,Peter J. Mohler,Jie Sun,Silvia Guatimosim,Long-Sheng Song,Nora Rosemblit,Jeanine D'Armiento,Carlo Napolitano,Mirella Memmi,Silvia G. Priori,W. J. Lederer,Andrew R. Marks +15 more
TL;DR: It is shown that during exercise, RyR2 phosphorylation by cAMP-dependent protein kinase A (PKA) partially dissociates FKBP12.6 from the channel, increasing intracellular Ca(2+) release and cardiac contractility, suggesting that "leaky"RyR2 channels can trigger fatal cardiac arrhythmias.
Journal ArticleDOI
Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes
Peter J. Mohler,Ilaria Rivolta,Carlo Napolitano,Guy Lemaillet,Stephen Lambert,Silvia G. Priori,Vann Bennett +6 more
TL;DR: Results in cardiomyocytes suggest that ankyrin-G participates in a common pathway for localization of voltage-gated Na(v) channels at sites of function in multiple excitable cell types.
Journal ArticleDOI
CaMKII determines mitochondrial stress responses in heart
Mei Ling A. Joiner,Olha M. Koval,Jingdong Li,Jingdong Li,B. Julie He,Chantal Allamargot,Zhan Gao,Elizabeth D. Luczak,Duane D. Hall,Brian D. Fink,Biyi Chen,Jinying Yang,Steven A. Moore,Thomas D. Scholz,Stefan Strack,Peter J. Mohler,Peter J. Mohler,William I. Sivitz,William I. Sivitz,Long-Sheng Song,Mark E. Anderson +20 more
TL;DR: CaMKII activity is identified as a central mechanism for mitochondrial Ca2+ entry in myocardial cell death, and indicates that mitochondrial-targeted CaMKII inhibition could prevent or reduce myocardials death and heart failure in response to common experimental forms of pathophysiological stress.