P
Peter J. Peters
Researcher at Maastricht University
Publications - 187
Citations - 36258
Peter J. Peters is an academic researcher from Maastricht University. The author has contributed to research in topics: Endosome & Stem cell. The author has an hindex of 77, co-authored 173 publications receiving 31358 citations. Previous affiliations of Peter J. Peters include Delft University of Technology & Netherlands Cancer Institute.
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Journal ArticleDOI
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Toshiro Sato,Robert G.J. Vries,Hugo J. Snippert,Marc van de Wetering,Nick Barker,Daniel E. Stange,Johan H. van Es,Arie Abo,Pekka Kujala,Peter J. Peters,Hans Clevers +10 more
TL;DR: It is concluded that intestinal cryptvillus units are self-organizing structures, which can be built from a single stem cell in the absence of a non-epithelial cellular niche.
Journal ArticleDOI
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker,Johan H. van Es,Jeroen Kuipers,Pekka Kujala,Maaike van den Born,Miranda Cozijnsen,Andrea Haegebarth,Jeroen Korving,Harry Begthel,Peter J. Peters,Hans Clevers +10 more
TL;DR: The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers, suggesting that it represents the stem cell of the small intestine and colon.
Journal ArticleDOI
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4.
Vladimir Korinek,Nick Barker,Petra Moerer,E van Donselaar,Gerwin Huls,Peter J. Peters,Hans Clevers +6 more
TL;DR: The role of Tcf-4 in colon cancer was investigated in this paper, where the authors found that Tcf7/2//- mice die shortly after birth from colon cancer.
Journal ArticleDOI
Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
Nick Barker,Meritxell Huch,Pekka Kujala,Marc van de Wetering,Hugo J. Snippert,Johan H. van Es,Toshiro Sato,Daniel E. Stange,Harry Begthel,Maaike van den Born,Esther Danenberg,Stieneke van den Brink,Jeroen Korving,Arie Abo,Peter J. Peters,Peter J. Peters,Nicholas A. Wright,Richard Poulsom,Hans Clevers +18 more
TL;DR: The Lgr5 stem cell marker and culture method described here will be invaluable tools for accelerating research into gastric epithelial renewal, inflammation/infection, and cancer.
Journal ArticleDOI
SARS-CoV-2 productively infects human gut enterocytes.
Mart M. Lamers,Joep Beumer,Jelte van der Vaart,Kèvin Knoops,Jens Puschhof,Tim I Breugem,Raimond B. G. Ravelli,J. Paul van Schayck,Anna Z Mykytyn,Hans Duimel,Elly van Donselaar,Samra Riesebosch,Helma J.H. Kuijpers,Debby Schipper,Willine J. van de Wetering,Miranda de Graaf,Marion Koopmans,Edwin Cuppen,Peter J. Peters,Bart L. Haagmans,Hans Clevers +20 more
TL;DR: It is demonstrated that intestinal organoids can serve as a model to understand SARS-CoV-2 biology and infectivity in the gut, and hSIOs serve as an experimental model for coronavirus infection and biology.