P
Peter J. Shaughnessy
Publications - 1
Citations - 74
Peter J. Shaughnessy is an academic researcher. The author has contributed to research in topics: Ubiquitin ligase & mitochondrial fusion. The author has an hindex of 1, co-authored 1 publications receiving 67 citations.
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Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling.
Kristi L. Norris,Rui Hao,Liang-Fu Chen,Chun-Hsiang Lai,Meghan Kapur,Peter J. Shaughnessy,Dennis Chou,Jin Yan,J. Paul Taylor,Simone Engelender,Anna E. West,Kah-Leong Lim,Tso-Pang Yao +12 more
TL;DR: Under moderate mitochondrial stress conditions, parkin stimulates mitochondrial fusion instead of mitophagy by catalyzing K63-linked ubiquitination and inactivating α-synuclein, which provides a physiological context to functionally connect key PARK genes in the pathogenesis of Parkinson disease.