P
Peter Jenner
Researcher at King's College London
Publications - 733
Citations - 57278
Peter Jenner is an academic researcher from King's College London. The author has contributed to research in topics: Dopamine & Substantia nigra. The author has an hindex of 109, co-authored 698 publications receiving 54102 citations. Previous affiliations of Peter Jenner include University of Lausanne & University of Cambridge.
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Mitochondrial complex I deficiency in Parkinson's disease.
TL;DR: Results indicated a specific defect of Complex I activity in the substantia nigra of patients with Parkinson's disease, which adds further support to the proposition that Parkinson’s disease may be due to an environmental toxin with action(s) similar to those of MPTP.
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Oxidative stress in Parkinson's disease
TL;DR: Oxidative stress contributes to the cascade leading to dopamine cell degeneration in Parkinson's disease (PD), but oxidative stress is intimately linked to other components of the degenerative process, such as mitochondrial dysfunction, excitotoxicity, nitric oxide toxicity and inflammation.
Journal ArticleDOI
Mitochondrial complex I deficiency in Parkinson's disease.
Journal ArticleDOI
Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease
D. Dexter,C.J. Carter,F. R. Wells,F. Javoy-Agid,Yves Agid,Andrew J. Lees,Peter Jenner,C. D. Marsden +7 more
TL;DR: The results may indicate that an increased level of lipid peroxidation continues to occur in the parkinsonian nigra up to the time of death, perhaps because of continued exposure to excess free radicals derived from some endogenous or exogenous neurotoxic species.
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Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
Jeswinder Sian,D. T. Dexter,A. J. Lees,S. E. Daniel,Yves Agid,F. Javoy-Agid,Peter Jenner,C. D. Marsden +7 more
TL;DR: The altered GSH/GSSG ratio in the substantia nigra in Parkinson's disease is consistent with the concept of oxidative stress as a major component in the pathogenesis of nigral cell death in Parkinson’s disease.