P
Peter Krajcsi
Researcher at Semmelweis University
Publications - 89
Citations - 3632
Peter Krajcsi is an academic researcher from Semmelweis University. The author has contributed to research in topics: ATP-binding cassette transporter & Efflux. The author has an hindex of 33, co-authored 87 publications receiving 3366 citations. Previous affiliations of Peter Krajcsi include Pázmány Péter Catholic University & Saint Louis University.
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The role of ABC transporters in drug resistance, metabolism and toxicity.
TL;DR: This review provides a general overview of the human ABC transporters, their expression, localization and basic mechanism of action, and provides examples for their role in Absorption-Distribution-Metabolism-Excretion (ADME) and toxicology, and describes several basic assays which can be applied for screening drug interactions with ABCtransporters in the course of drug research and development.
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Tissue-Specific, Tumor-Selective, Replication-Competent Adenovirus Vector for Cancer Gene Therapy
Konstantin Doronin,Mohan Kuppuswamy,Karoly Toth,Ann E. Tollefson,Peter Krajcsi,Valeri Krougliak,William S. M. Wold +6 more
TL;DR: It is established that the adenovirus E4 promoter can be replaced by a tissue-specific promoter in a replication-competent vector.
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Overexpression of the ADP (E3-11.6K) protein increases cell lysis and spread of adenovirus.
Konstantin Doronin,Karoly Toth,Mohan Kuppuswamy,Peter Krajcsi,Ann E. Tollefson,William S. M. Wold +5 more
TL;DR: Two adenovirus mutants, namedVRX-006 and VRX-007, that overexpress ADP display the phenotype predicted by the proposed function for ADP: they produce early cytopathic effect, early cell lysis, large plaques, and increased cell-to-cell spread.
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ABCC2/Abcc2: a multispecific transporter with dominant excretory functions
Katalin Jemnitz,Krisztina Herédi-Szabó,Judit Janossy,Eniko Ioja,László Vereczkey,Peter Krajcsi +5 more
TL;DR: ABCC2/Abcc2 (MRP2/Mrp2) is expressed at major physiological barriers, such as the canalicular membrane of liver cells, kidney proximal tubule epithelial cells, enterocytes of the small and large intestine, and syncytiotrophoblast of the placenta.
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Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3).
Anne Lespine,J. Dupuy,Stéphane Orlowski,Tünde Nagy,Hristos Glavinas,Peter Krajcsi,Michel Alvinerie +6 more
TL;DR: Although Pgp has been considered until now as the sole active transporter for this drug, the MRPs should be taken into account for the transport of ivermectin across cell membrane, modulating its disposition in addition to Pgp.