P
Peter Mombaerts
Researcher at Massachusetts Institute of Technology
Publications - 22
Citations - 8994
Peter Mombaerts is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 21, co-authored 22 publications receiving 8678 citations. Previous affiliations of Peter Mombaerts include University of Ulm & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
RAG-1-deficient mice have no mature B and T lymphocytes
Peter Mombaerts,John Iacomini,Randall S. Johnson,Karl Herrup,Susumu Tonegawa,Virginia E. Papaioannou +5 more
TL;DR: The introduction of a mutation in RAG-1 into the germline of mice via gene targeting in embryonic stem cells is described and it is shown that this mutation either activates or catalyzes the V(D)J recombination reaction of immunoglobulin and T cell receptor genes.
Journal ArticleDOI
Visualizing an Olfactory Sensory Map
Peter Mombaerts,Fan Wang,Catherine Dulac,Steve K. Chao,Adriana Nemes,Monica Mendelsohn,James Edmondson,Richard Axel +7 more
TL;DR: A genetic approach is developed to visualize axons from olfactory sensory neurons expressing a given odorant receptor, as they project to the Olfactory bulb, which provides direct support for a model in which a topographic map of receptor activation encodes odor quality in the ofactory bulb.
Journal ArticleDOI
Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
Peter Mombaerts,Alan Richard Clarke,Michael A. Rudnicki,John Iacomini,Shigeyoshi Itohara,Juan J. Lafaille,Lili Wang,Yoshiaki Ichikawa,Rudolf Jaenisch,Martin L. Hooper,Susumu Tonegawa +10 more
TL;DR: Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that TCP-β gene rearrangement or expression is critical for the differentiation of CD4− CD8− thymocyte to CD4+CD8+ thymocytes, as well as for the expansion of the pool ofCD4+ CD8+ cells.
Journal ArticleDOI
Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice
Peter Mombaerts,Emiko Mizoguchi,Michael J. Grusby,Laurie H. Glimcher,Atul K. Bhan,Susumu Tonegawa +5 more
TL;DR: It is suggested that dysfunction of the mucosal immune system may underly the pathogenesis of some types of IBD in humans.
Journal ArticleDOI
T cell receptor δ gene mutant mice : independent generation of αβ T cells and programmed rearrangements of γδ TCR genes
Shigeyoshi Itohara,Peter Mombaerts,Juan J. Lafaille,John Iacomini,Andrew J. Nelson,Alan Richard Clarke,Martin L. Hooper,Andrew G. Farr,Susumu Tonegawa +8 more
TL;DR: The analyses of TCR γ and δ genes in the mutant mice suggest that intracellular mechanisms acting at the level of DNA rearrangement play key roles in the differential δ and γ gene rearrangements and in the generation of the highly restricted junctional sequences during fetal thymic development.