P
Peter Rose
Researcher at University of Nottingham
Publications - 44
Citations - 3579
Peter Rose is an academic researcher from University of Nottingham. The author has contributed to research in topics: Apoptosis & Medicine. The author has an hindex of 24, co-authored 38 publications receiving 3151 citations. Previous affiliations of Peter Rose include University of Lincoln & King's College London.
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Hydrogen Sulfide and Cell Signaling
TL;DR: Pharmacological experiments using H₂S donors and genetic experiments using CSE knockout mice suggest important roles for this vasodilator gas in the regulation of blood vessel caliber, cardiac response to ischemia/reperfusion injury, and inflammation.
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Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents.
TL;DR: The chemical diversity of S-alk(en)yl cysteine sulfoxide metabolites in the context of their biochemical and pharmacological mechanisms is discussed.
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The Effect of Hydrogen Sulfide Donors on Lipopolysaccharide-Induced Formation of Inflammatory Mediators in Macrophages
TL;DR: The effects of H(2)S on the inflammatory process are complex and dependent not only on H(1beta, IL-6, NO, PGE(2), and TNF-alpha but also on the rate of H2S generation, which may explain some of the apparent discrepancies in the literature regarding the pro- versus antiinflammatory role of the molecule.
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H2S biosynthesis and catabolism: new insights from molecular studies.
TL;DR: Recently, a number of laboratories have reported the use of siRNA methodologies and genetic mouse models to mimic the loss of function of genes involved in the biosynthesis and degradation of H2S within tissues, revealing new insights into the biology of H20 within the cardiovascular system, inflammatory disease, and in cell signalling.
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Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells
TL;DR: The data indicate that isothiocyanates derived form broccoli and Rorripa inhibit metalloproteinase 9 activities and also suppress the invasive potential of human MDA-MB-231 breast cancer cells in vitro.