P
Peter T. Hraber
Researcher at Los Alamos National Laboratory
Publications - 98
Citations - 10152
Peter T. Hraber is an academic researcher from Los Alamos National Laboratory. The author has contributed to research in topics: Virus & Simian immunodeficiency virus. The author has an hindex of 42, co-authored 98 publications receiving 9183 citations. Previous affiliations of Peter T. Hraber include Santa Fe Institute & National Center for Genome Resources.
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Journal ArticleDOI
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
Hua-Xin Liao,Rebecca M. Lynch,Tongqing Zhou,Feng Gao,Feng Gao,S. Munir Alam,S. Munir Alam,Scott D. Boyd,Andrew Fire,Krishna M. Roskin,Chaim A. Schramm,Zhenhai Zhang,Jiang Zhu,Lawrence Shapiro,Lawrence Shapiro,Nisc Comparative Sequencing Program,James C. Mullikin,Sandrasegaram Gnanakaran,Peter T. Hraber,Kevin Wiehe,Kevin Wiehe,Garnett Kelsoe,Garnett Kelsoe,Guang Yang,Guang Yang,Shi-Mao Xia,Shi-Mao Xia,David C. Montefiori,David C. Montefiori,Robert Parks,Robert Parks,Krissey E. Lloyd,Krissey E. Lloyd,Richard M. Scearce,Richard M. Scearce,Kelly A. Soderberg,Kelly A. Soderberg,Myron S. Cohen,Gift Kamanga,Mark K. Louder,Lillian Tran,Yue Chen,Yue Chen,Fangping Cai,Fangping Cai,Sheri Chen,Sheri Chen,Stephanie Moquin,Xiulian Du,M. Gordon Joyce,Sanjay Srivatsan,Baoshan Zhang,Anqi Zheng,George M. Shaw,Beatrice H. Hahn,Thomas B. Kepler,Bette T. Korber,Peter D. Kwong,John R. Mascola,Barton F. Haynes,Barton F. Haynes +60 more
TL;DR: The isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection and its co-crystal structure revealed a new loop-based mechanism of CD4-binding-site recognition.
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Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection.
Jesus F. Salazar-Gonzalez,Maria G. Salazar,Brandon F. Keele,Gerald H. Learn,Elena E. Giorgi,Elena E. Giorgi,Hui Li,Julie M. Decker,Shuyi Wang,Joshua Baalwa,Matthias H. Kraus,Nicholas F. Parrish,Katharina S. Shaw,M. Brad Guffey,Katharine J. Bar,Katie L. Davis,Christina Ochsenbauer-Jambor,John C. Kappes,Michael S. Saag,Myron S. Cohen,Joseph Mulenga,Cynthia A. Derdeyn,Susan Allen,Eric Hunter,Martin Markowitz,Martin Markowitz,Peter T. Hraber,Alan S. Perelson,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Barton F. Haynes,Bette T. Korber,Bette T. Korber,Beatrice H. Hahn,George M. Shaw +34 more
TL;DR: Viral properties associated with mucosal HIV-1 transmission and a limited set of rapidly evolving adaptive mutations driven primarily, but not exclusively, by early cytotoxic T cell responses are revealed.
Journal ArticleDOI
The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
Nilu Goonetilleke,Michael K. P. Liu,Jesus F. Salazar-Gonzalez,Guido Ferrari,Elena E. Giorgi,Vitaly V. Ganusov,Brandon F. Keele,Gerald H. Learn,Emma L. Turnbull,Maria G. Salazar,Kent J. Weinhold,Stephen Moore,Norman L. Letvin,Barton F. Haynes,Myron S. Cohen,Peter T. Hraber,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Persephone Borrow,Alan S. Perelson,Beatrice H. Hahn,George M. Shaw,Bette T. Korber,Bette T. Korber,Andrew J. McMichael +24 more
TL;DR: Kinetic analysis and mathematical modeling of virus immune escape showed that the contribution of CD8 T cell–mediated killing of productively infected cells was earlier and much greater than previously recognized and that it contributed to the initial decline of plasma virus in acute infection.
Journal Article
Revisiting the Edge of Chaos: Evolving Cellular Automata to Perform Computations
TL;DR: Mitchell et al. as discussed by the authors presented results from an experiment similar to one performed by Packard (1988), in which a genetic algorithm is used to evolve cellular automata (CA) to perform a particular computational task.
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Evolving cellular automata to perform computations: mechanisms and impediments
TL;DR: The extent to which symmetry breaking and other impediments are general phenomena in any GA search is discussed, and four “epochs of innovation” in which new CA strategies for solving the problem are discovered by the GA are identified.