Péter Várnai

TL;DR: An unexpected dependence of cell function and survival is revealed on the maintenance of proper spacing between the ER and mitochondria, which makes mitochondria prone to Ca2+ overloading and ensuing permeability transition.

TL;DR: It is demonstrated that VDAC1 is physically linked to the endoplasmic reticulum Ca2+-release channel inositol 1,4,5-trisphosphate receptor (IP3R) through the molecular chaperone glucose-regulated protein 75 (grp75) and functional interaction between the channels was shown by the recombinant expression of the ligand-binding domain of the IP3R on the ER or mitochondrial surface.

TL;DR: The data suggest that Renox, as a renal source of reactive oxygen species, is a likely candidate for the oxygen sensor function regulating oxygen-dependent gene expression and may also have a role in the development of inflammatory processes in the kidney.

TL;DR: In this paper, the PLC(4,5)P2 pools that bind pleckstrin homology (PH) domains were visualized by cellular expression of a PLCδ PH domain and analysis of confocal images in living cells.

TL;DR: Identification and dynamic imaging of phosphoinositides that interact with PH domains will further the understanding of the regulation of such proteins by inositol phospholipids.