P
Peter W. J. Rigby
Researcher at Institute of Cancer Research
Publications - 64
Citations - 7566
Peter W. J. Rigby is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: MYF5 & Myogenesis. The author has an hindex of 42, co-authored 64 publications receiving 7242 citations. Previous affiliations of Peter W. J. Rigby include National Institute for Medical Research.
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Journal ArticleDOI
A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.
Mitchell H. Rosner,M A Viganò,Keiko Ozato,P. M. Timmons,F. Poirier,F. Poirier,Peter W. J. Rigby,Louis M. Staudt +7 more
TL;DR: The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain, which is expressed in the totipotent and pluripotent stem cells of the pre-gastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development.
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Know Your Neighbors: Three Phenotypes in Null Mutants of the Myogenic bHLH Gene MRF4
TL;DR: Until substantially more is understood about cis-regulation over substantial regions of the genome it is prudent to consider these effects in design and in interpretation.
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Gene Regulatory Networks and Transcriptional Mechanisms that Control Myogenesis
TL;DR: The upstream regulators of myogenesis that lead to the activation of myogenic determination genes and subsequent differentiation, focusing on the mouse model, are discussed, with new insights into mechanisms underlying the transcriptional activity of these factors.
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The regulation of myogenin gene expression during the embryonic development of the mouse
Siu-Pok Yee,Peter W. J. Rigby +1 more
TL;DR: It is concluded that the proper regulation of myogenin requires a bHLH protein, most probably Myf-5, the only myogenic b HLH factor known to be present in the embryo at the time thatmyogenin is activated, and an RSRF-like binding activity.
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McrA and McrB restriction phenotypes of some E.coli strains and implications for gene cloning
Elisabeth A. Raleigh,Noreen E. Murray,H. Revel,Robert Blumenthal,D. Westaway,A. D. Reith,Peter W. J. Rigby,Jeff Elhai,D. Hanahan +8 more
TL;DR: Evidence is reviewed suggesting that McrB restriction of mouse-modified DNA does occur in vivo and does in fact interfere with cloning of specific mouse sequences.