P
Peter W. Swaan
Researcher at University of Maryland, Baltimore
Publications - 125
Citations - 10668
Peter W. Swaan is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: SLC10A2 & Bile acid. The author has an hindex of 46, co-authored 124 publications receiving 9771 citations. Previous affiliations of Peter W. Swaan include Ohio State University & University of Maryland, College Park.
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Journal ArticleDOI
Membrane transporters in drug development.
Kathleen M. Giacomini,Shiew-Mei Huang,Donald J. Tweedie,Leslie Z. Benet,Kim L. R. Brouwer,Xiaoyan Chu,Amber Dahlin,Raymond Evers,Volker Fischer,Kathleen M. Hillgren,Keith Hoffmaster,Toshihisa Ishikawa,Dietrich Keppler,Richard B. Kim,Caroline A. Lee,Mikko Niemi,Joseph W. Polli,Yuicchi Sugiyama,Peter W. Swaan,Joseph A. Ware,Stephen H. Wright,Sook Wah Yee,Maciej J. Zamek-Gliszczynski,Lei Zhang +23 more
TL;DR: Overall, it is advised that the timing of transporter investigations should be driven by efficacy, safety and clinical trial enrolment questions, as well as a need for further understanding of the absorption, distribution, metabolism and excretion properties of the drug molecule, and information required for drug labelling.
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Endocytic mechanisms for targeted drug delivery
Lisa M. Bareford,Peter W. Swaan +1 more
TL;DR: Current work is investigating a synthetic receptor approach for high affinity binding of targeted macromolecules to the endolysosomal pathway, which has serious potential for improving drug delivery for the treatment of lysosomal storage diseases, cancer, and Alzheimer's disease.
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Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration.
Savita Khanna,Sashwati Roy,Hoon Ryu,Praveen M. Bahadduri,Peter W. Swaan,Rajiv R. Ratan,Chandan K. Sen +6 more
TL;DR: This study on HT4 and immature primary cortical neurons suggests a central role of 12-lipoxygenase (12-LOX) in executing glutamate-induced neurodegeneration and lends further support to α-tocotrienol as a potent neuroprotective form of vitamin E.
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Surface Acetylation of Polyamidoamine (PAMAM) Dendrimers Decreases Cytotoxicity while Maintaining Membrane Permeability
TL;DR: Cytotoxicity was reduced by more than 10-fold as the number of surface acetyl groups increased while maintaining permeability across the cell monolayers, and a decrease in nonspecific binding was evident for surface-modified dendrimers compared to their unmodified counterparts.
Journal ArticleDOI
Camptothecins: a review of their chemotherapeutic potential.
Hulya Ulukan,Peter W. Swaan +1 more
TL;DR: This review illustrates the proposed mechanism(s) of action of camptothecins and presents a concise overview of current and novel analogues undergoing clinical trails, such as exatecan (DX-8951f), IDEC-132 (9-aminocamptothecin), rubitecan (9