Peter Wieghofer

TL;DR: It is determined that short-chain fatty acids (SCFA), microbiota-derived bacterial fermentation products, regulated microglia homeostasis and mice deficient for the SCFA receptor FFAR2 mirroredmicroglia defects found under GF conditions, suggesting that host bacteria vitally regulate microglian maturation and function.

TL;DR: It is found that mouse microglia were derived from primitive c-kit+ erythromyeloid precursors that were detected in the yolk sac as early as 8 d post conception and microgliogenesis was not only dependent on the transcription factor Pu.1, but also required Irf8, which was vital for the development of the A2 population, whereas Myb, Id2, Batf3 and Klf4 were not required.

TL;DR: Using parabiosis and fate-mapping approaches in mice, it is found that CNS macrophages arose from hematopoietic precursors during embryonic development and established stable populations, with the notable exception of choroid plexus macrophage, which had dual origins and a shorter life span.

TL;DR: A mouse experimental system that specifically targets microglia found TAK1 to be pivotal in CNS autoimmunity, and it is presented as a tool for future investigations of microglial function in the CNS.

TL;DR: The liver is identified as the primary organ that supports rapid erythrocyte removal and iron recycling, and a mechanism by which the body adapts to fluctuations in ery throatcyte integrity is uncovered.