P
Petr Cejka
Researcher at University of Lugano
Publications - 98
Citations - 6647
Petr Cejka is an academic researcher from University of Lugano. The author has contributed to research in topics: Homologous recombination & DNA repair. The author has an hindex of 38, co-authored 89 publications receiving 5405 citations. Previous affiliations of Petr Cejka include École Polytechnique Fédérale de Lausanne & ETH Zurich.
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Journal ArticleDOI
DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2
Petr Cejka,Elda Cannavo,Piotr Polaczek,Taro Masuda-Sasa,Subhash Pokharel,Judith L. Campbell,Stephen C. Kowalczykowski +6 more
TL;DR: It is established that Dna2, Sgs1 and RPA constitute a minimal protein complex capable of DNA resection in vitro and that both the topoisomerase 3 and Rmi1 complex and the Mre11–Rad50–Xrs2 complex (MRX) have important roles as stimulatory components.
Journal ArticleDOI
Pif1 family helicases suppress genome instability at G-quadruplex motifs
Katrin Paeschke,Katrin Paeschke,Matthew L. Bochman,P. Daniela Garcia,Petr Cejka,Petr Cejka,Katherine L. Friedman,Stephen C. Kowalczykowski,Virginia A. Zakian +8 more
TL;DR: It is shown that exceptionally potent G- quadruplex unwinding is conserved among Pif1 helicases, and when expressed in yeast, human PIF1 suppressed both G-quadruplex-associated DNA damage and telomere lengthening.
Journal ArticleDOI
Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks
Elda Cannavo,Petr Cejka +1 more
TL;DR: Using purified Saccharomyces cerevisiae proteins, it is shown that Sae2 promotes ds DNA-specific endonuclease activity by the Mre11 subunit within the MRX complex, demonstrating a probable mechanism for the initiation of dsDNA break processing in both vegetative and meiotic cells.
Journal ArticleDOI
DNA2 drives processing and restart of reversed replication forks in human cells
Saravanabhavan Thangavel,Matteo Berti,Maryna Levikova,Cosimo Pinto,Shivasankari Gomathinayagam,Marko Vujanovic,Ralph Zellweger,Hayley R. Moore,Eu Han Lee,Eric A. Hendrickson,Petr Cejka,Sheila A. Stewart,Massimo Lopes,Alessandro Vindigni +13 more
TL;DR: Following prolonged genotoxic stress, DNA2 and WRN functionally interact to degrade reversed replication forks and promote replication restart, thereby preventing aberrant processing of unresolved replication intermediates.
Journal ArticleDOI
Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.
Angelo Taglialatela,Silvia Alvarez,Giuseppe Leuzzi,Vincenzo Sannino,Lepakshi Ranjha,Jen-Wei Huang,Chioma J. Madubata,Roopesh Anand,Brynn Levy,Raul Rabadan,Petr Cejka,Petr Cejka,Vincenzo Costanzo,Alberto Ciccia +13 more
TL;DR: In this paper, the authors show that depletion of SMARCAL1, a SNF2-family DNA translocase that remodels stalled forks, restores replication fork stability and reduces the formation of replication stress-induced DNA breaks and chromosomal aberrations in BRCA1/2-deficient cells.