P
Philip E. Auron
Researcher at Duquesne University
Publications - 110
Citations - 12517
Philip E. Auron is an academic researcher from Duquesne University. The author has contributed to research in topics: Complementary DNA & Transcription factor. The author has an hindex of 47, co-authored 109 publications receiving 11618 citations. Previous affiliations of Philip E. Auron include Harvard University & Tufts University.
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Journal ArticleDOI
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill,Anne M. Curtis,Juraj Adamik,Eva M. Palsson-McDermott,Anne F. McGettrick,Gautam Goel,Christian Frezza,Nicholas J. Bernard,Beth Kelly,Niamh Foley,Liang Zheng,A. Gardet,Zhen Tong,S. S. Jany,Sinéad C. Corr,Moritz Haneklaus,Brian E. Caffrey,Kerry A. Pierce,Sarah R. Walmsley,F. C. Beasley,Eoin P. Cummins,Victor Nizet,Moira K. B. Whyte,Cormac T. Taylor,Hening Lin,Seth L. Masters,Eyal Gottlieb,Vincent P. Kelly,Clary B. Clish,Philip E. Auron,Ramnik J. Xavier,Ramnik J. Xavier,Luke A. J. O'Neill +32 more
TL;DR: The authors showed that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages.
Journal ArticleDOI
Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.
Alexzander Asea,Michael Rehli,Edith Kabingu,Jason A. Boch,Olivia Baré,Philip E. Auron,Mary Ann Stevenson,Stuart K. Calderwood +7 more
TL;DR: It is demonstrated that exogenously added HSP70 possesses potent cytokine activity, with the ability to bind with high affinity to the plasma membrane, elicit a rapid intracellular Ca2+ flux, activate NF-κB, and up-regulate the expression of pro-inflammatory cytokines in human monocytes.
Journal ArticleDOI
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.
Philip E. Auron,Andrew C. Webb,Lanny J. Rosenwasser,Steven F. Mucci,Alexander Rich,Sheldon M. Wolff,Charles A. Dinarello +6 more
TL;DR: The cDNA nucleotide sequence suggests that IL-1 is initially translated as a precursor molecule that is subsequently processed into the 15,000-20,000 Mr protein usually associated with IL- 1 activity.
Journal ArticleDOI
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFκB
TL;DR: U-STAT3 sustains cytokine-dependent signaling at late times through a mechanism completely distinct from that used by P-STAT2, and is likely to be important in physiological responses to gp130-linked cytokines and growth factors that activate STAT3, and in cancers that have constitutively active P- STAT3.
Journal ArticleDOI
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1.
Pu Zhang,Gerhard Behre,Jing Pan,Atsushi Iwama,Nawarat Wara-aswapati,Hanna S. Radomska,Philip E. Auron,Daniel G. Tenen,Zijie Sun +8 more
TL;DR: Interactions between PU.1 and GATA proteins play a critical role in the decision of stem cells to commit to erythroid vs. myeloid lineages, suggesting that normal hematopoietic lineage development is under threat.