P
Philip J. Norris
Researcher at University of California, San Francisco
Publications - 194
Citations - 9161
Philip J. Norris is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Immune system & Viral load. The author has an hindex of 49, co-authored 179 publications receiving 7758 citations. Previous affiliations of Philip J. Norris include Australian Red Cross Blood Service & Harvard University.
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Journal ArticleDOI
Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections
Andrea Stacey,Philip J. Norris,Philip J. Norris,Li Qin,Li Qin,E Haygreen,Elizabeth Taylor,John W. Heitman,Mila Lebedeva,Allan C. deCamp,Dongfeng Li,Dongfeng Li,Douglas I. Grove,Steven G. Self,Steven G. Self,Persephone Borrow +15 more
TL;DR: The intense early cytokine storm in acute HIV-1 infection may have immunopathological consequences, promoting immune activation, viral replication, and CD4+ T-cell loss.
Journal ArticleDOI
Transfusion-related acute lung injury: Incidence and risk factors
Pearl Toy,Ognjen Gajic,Peter Bacchetti,Mark R. Looney,Michael A. Gropper,Rolf D. Hubmayr,Clifford A. Lowell,Philip J. Norris,Philip J. Norris,Edward L. Murphy,Edward L. Murphy,Richard B. Weiskopf,Gregory A. Wilson,Monique Koenigsberg,Deanna C. Lee,Randy M. Schuller,Ping Wu,Barbara Grimes,Manish J. Gandhi,Jeffrey L. Winters,David C. Mair,Nora V. Hirschler,Nora V. Hirschler,Rosa Sanchez Rosen,Rosa Sanchez Rosen,Michael A. Matthay +25 more
TL;DR: The identified risk factors provide potential targets for reducing residual TRALI and little or no risk was associated with older red blood cell units, noncognate or weak cognate class II antibody, or class I antibody.
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The effect of previous pregnancy and transfusion on HLA alloimmunization in blood donors: implications for a transfusion-related acute lung injury risk reduction strategy
Darrell J. Triulzi,Steven Kleinman,Ram Kakaiya,Michael P. Busch,Philip J. Norris,Whitney R. Steele,Simone A. Glynn,Christopher D. Hillyer,Patricia M. Carey,Jerome L. Gottschall,Edward L. Murphy,Jorge A. Rios,Paul M. Ness,David Wright,Danielle M. Carrick,George B. Schreiber +15 more
TL;DR: The prevalence of HLA antibodies and their relationship to previous transfusion or pregnancy in blood donors was determined and a potential measure to reduce the risk of TRALI includes screening plateletpheresis donors for HLA antibody screening.
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IL-1β Signaling Promotes CNS-Intrinsic Immune Control of West Nile Virus Infection
Hilario J. Ramos,Marion C. Lanteri,Gabriele Blahnik,Amina Negash,Mehul S. Suthar,Margaret M. Brassil,Khushbu Sodhi,Piper M. Treuting,Michael P. Busch,Michael P. Busch,Philip J. Norris,Philip J. Norris,Michael Gale +12 more
TL;DR: The NLRP3 inflammasome pathway and IL-1β signaling are defined as key features controlling WNV infection and immunity in the CNS, and a novel role for IL- 1β in antiviral action that restricts virus replication in neurons is revealed.
Journal ArticleDOI
Evidence for Persistent Low-Level Viremia in Individuals Who Control Human Immunodeficiency Virus in the Absence of Antiretroviral Therapy
Hiroyu Hatano,Eric Delwart,Eric Delwart,Philip J. Norris,Philip J. Norris,Tzong-Hae Lee,Joan Dunn-Williams,Peter W. Hunt,Rebecca Hoh,Susan L. Stramer,Jeffrey M. Linnen,Joseph M. McCune,Jeffrey N. Martin,Michael P. Busch,Steven G. Deeks +14 more
TL;DR: The failure to eradicate the virus is confirmed even in these unique individuals who are able to reduce plasma viremia to very low levels without antiretroviral therapy.