P
Philip J. R. Goulder
Researcher at University of Oxford
Publications - 319
Citations - 34971
Philip J. R. Goulder is an academic researcher from University of Oxford. The author has contributed to research in topics: Human leukocyte antigen & Epitope. The author has an hindex of 84, co-authored 295 publications receiving 32080 citations. Previous affiliations of Philip J. R. Goulder include John Radcliffe Hospital & Massachusetts Institute of Technology.
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Journal ArticleDOI
Phenotypic Analysis of Antigen-Specific T Lymphocytes
John D. Altman,Paul Moss,Philip J. R. Goulder,Dan H. Barouch,Michael G. McHeyzer-Williams,John I. Bell,Andrew J. McMichael,Mark M. Davis +7 more
TL;DR: Tetramers of human lymphocyte antigen A2 that were complexed with two different human immunodeficiency virus (HIV)-derived peptides or with a peptide derived from influenza A matrix protein bound to peptide-specific cytotoxic T cells in vitro and to T cells from the blood of HIV-infected individuals and correlated well with cytotoxicity assays.
Journal ArticleDOI
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Cheryl L. Day,Daniel Kaufmann,Photini Kiepiela,Julia A. Brown,Eshia Moodley,Sharon Reddy,Elizabeth W Mackey,Joseph D. Miller,Alasdair Leslie,Chantal DePierres,Zenele Mncube,Jaikumar Duraiswamy,Baogong Zhu,Quentin Eichbaum,Marcus Altfeld,E. John Wherry,Hoosen M. Coovadia,Philip J. R. Goulder,Philip J. R. Goulder,Philip J. R. Goulder,Paul Klenerman,Rafi Ahmed,Gordon J. Freeman,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker +25 more
TL;DR: The data indicate that the immunoregulatory PD-1/PD-L1 pathway is operative during a persistent viral infection in humans, and define a reversible defect in HIV-specific T-cell function.
Journal ArticleDOI
Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS.
Philip J. R. Goulder,Rodney E. Phillips,Robert A. Colbert,S McAdam,Graham S. Ogg,Martin A. Nowak,P. Giangrande,Graz Luzzi,B. Morgan,Alison J. Edwards,Andrew J. McMichael,Sarah Rowland-Jones +11 more
TL;DR: Six donors who make a strong CTL response to an immunodominant HLA-B27-restricted epitope and two donors who progressed to AIDS, CTL escape to fixation by the same mutation was observed, but only after 9–12 years of epitope stability.
Journal ArticleDOI
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
Photini Kiepiela,Kholiswa C. Ngumbela,Christina F. Thobakgale,Dhanwanthie Ramduth,Isobella Honeyborne,Eshia Moodley,Shabashini Reddy,Chantal de Pierres,Zenele Mncube,Nompumelelo Mkhwanazi,Karen S. Bishop,Mary van der Stok,Kriebashnie Nair,Nasreen Khan,Hayley Crawford,Rebecca Payne,Alasdair Leslie,Julia G. Prado,Andrew J. Prendergast,John Frater,Noel D. McCarthy,Christian Brander,Gerald H. Learn,David C. Nickle,Christine Rousseau,Hoosen M. Coovadia,James I. Mullins,David Heckerman,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Philip J. R. Goulder,Philip J. R. Goulder +32 more
TL;DR: A comprehensive analysis of the 160 dominant CD8+ T-cell responses in 578 untreated HIV-infected individuals from KwaZulu-Natal, South Africa suggested the existence of both effective immune responses and responses lacking demonstrable biological impact in chronic HIV infection.
Journal ArticleDOI
Immune control of HIV-1 after early treatment of acute infection
Eric S. Rosenberg,Marcus Altfeld,Samuel H. Poon,Mary N. Phillips,Barbara M. Wilkes,Robert L. Eldridge,Gregory K. Robbins,Richard T. D'Aquila,Philip J. R. Goulder,Bruce D. Walker +9 more
TL;DR: It is shown that, despite rebound in viraemia, all subjects were able to achieve at least a transient steady state off therapy with viral load below 5,000 RNA copies per ml, suggesting that functional immune responses can be augmented in a chronic viral infection.