Philip W. Fowler

TL;DR: Genotypic predictions of the susceptibility of M. tuberculosis to first‐line drugs were found to be correlated with phenotypic susceptibility to these drugs.

TL;DR: The crystal structure of PepTSo is presented, a functionally similar prokaryotic homologue of the mammalian peptide transporters from Shewanella oneidensis, which reveals a ligand‐bound occluded state for the MFS and provides new insights into a general transport mechanism.

TL;DR: Risks were heterogenous across the hospital, with higher rates in acute medicine, and sporadic outbreaks in areas with few or no Covid-19 patients.

TL;DR: Crystallized in an inward open conformation the structure identifies a hinge‐like movement within the C‐terminal half of the transporter that facilitates opening of an intracellular gate controlling access to a central peptide‐binding site, which supports a model for peptide transport that highlights the importance of salt bridge interactions in orchestrating alternating access within the POT family.

TL;DR: A recently developed hybrid continuum-molecular model, HybridMD, and its associated molecular insertion algorithm are described, which point the way towards the integration of molecular and more coarse-grained representations of matter.