P
Philippe A. Melas
Researcher at Karolinska University Hospital
Publications - 36
Citations - 1319
Philippe A. Melas is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Nucleus accumbens & Medicine. The author has an hindex of 15, co-authored 31 publications receiving 1036 citations. Previous affiliations of Philippe A. Melas include Columbia University & Karolinska Institutet.
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Journal ArticleDOI
Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities.
Philippe A. Melas,Ya Bin Wei,Ya Bin Wei,Chloe C. Y. Wong,Louise K. Sjöholm,Louise K. Sjöholm,Elin Åberg,Elin Åberg,Jonathan Mill,Martin Schalling,Martin Schalling,Yvonne Forsell,Catharina Lavebratt,Catharina Lavebratt +13 more
TL;DR: Depression in females may result from a gene × childhood-adversity interaction and/or a dysregulated epigenetic programming of MAOA, and childhood- adversity subtypes may differentially impact DNA methylation at NR3C1; baseline MAOA-genotypic variations may affect the extent of NR 3C1 methylation.
Journal ArticleDOI
Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset
Philippe A. Melas,Maria Rogdaki,Urban Ösby,Martin Schalling,Catharina Lavebratt,Tomas J. Ekström +5 more
TL;DR: The notion of a dysregulated epigenome in schizophrenia, which is more pronounced in early‐onset patients and can be partly rescued by antipsychotic medication, is supported and blood DNA‐methylation signatures show promise of serving as a schizophrenia biomarker in the future.
Journal ArticleDOI
Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres
L Martinsson,Ya Bin Wei,Ya Bin Wei,D Xu,Philippe A. Melas,Philippe A. Melas,Aleksander A. Mathé,Martin Schalling,Martin Schalling,Catharina Lavebratt,Catharina Lavebratt,Lena Backlund,Lena Backlund +12 more
TL;DR: The data suggest that lithium exerts a protective effect against telomere shortening especially when therapeutically efficacious, and hypothesize that induction of telomerase activity may be involved in LiR in BD patients.
Journal ArticleDOI
Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression.
Philippe A. Melas,Maria Rogdaki,Andreas Lennartsson,Karl Björk,Hongshi Qi,Anna Witasp,Martin Werme,Gregers Wegener,Aleksander A. Mathé,Per Svenningsson,Catharina Lavebratt +10 more
TL;DR: In this paper, the prefrontal cortex of the Flinders Sensitive Line (FSL) genetic rodent model of depression was found to be hypermethylated after chronic administration of escitalopram (a selective serotonin reuptake inhibitor; SSRI).
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Antidepressant-Like Effect of Sodium Butyrate is Associated with an Increase in TET1 and in 5-Hydroxymethylation Levels in the Bdnf Gene
TL;DR: The data support the antidepressant efficacy of HDACis and suggest that their epigenetic effects may also include DNA methylation changes that are mediated by demethylation-facilitating enzymes like TET1.