P
Philippe Clézardin
Researcher at University of Lyon
Publications - 227
Citations - 11739
Philippe Clézardin is an academic researcher from University of Lyon. The author has contributed to research in topics: Bone metastasis & Cancer. The author has an hindex of 61, co-authored 221 publications receiving 10852 citations. Previous affiliations of Philippe Clézardin include Harvard University & University of Bern.
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Journal Article
Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases.
Sandrine Boissier,Mercedes Ferreras,Olivier Peyruchaud,Sandrine Magnetto,F H Ebetino,Marc Colombel,Pierre D. Delmas,Jean-Marie Delaissé,Philippe Clézardin +8 more
TL;DR: Evidence that BP pretreatment of breast and prostate carcinoma cells inhibited tumor cell invasion in a dose-dependent manner is provided and BPs may be useful agents for the prophylactic treatment of patients with cancers that are known to preferentially metastasize to bone is suggested.
Journal Article
Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats.
Pierrick G.J. Fournier,Sandrine Boissier,Stephanie Filleur,Julien Guglielmi,Florence Cabon,Marc Colombel,Philippe Clézardin +6 more
TL;DR: BPs have in vivo antiangiogenic properties, which could be of relevance to improve therapy and prevention of bone metastasis, and extend the potential clinical use of BPs to patients with early prostate cancer.
Journal ArticleDOI
Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer
Ahmed Boucharaba,Claire-Marie Serre,Sandra Grès,Jean Sébastien Saulnier-Blache,Jean-Claude Bordet,Julien Guglielmi,Philippe Clézardin,Olivier Peyruchaud +7 more
TL;DR: The data suggest that, at the bone metastatic site, tumor cells stimulate the production of LPA from activated platelets, which enhances both tumor growth and cytokine-mediated bone destruction.
Journal Article
Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices
Sandrine Boissier,Sandrine Magnetto,Lucien Frappart,Béatrice Cuzin,F H Ebetino,Pierre D. Delmas,Philippe Clézardin +6 more
TL;DR: Evidence is provided for a direct cellular effect of BP in preventing tumor cell adhesion to bone, suggesting that BPs may be useful agents for the prophylactic treatment of patients with cancer that is known to preferentially metastasize to bone.
Journal Article
SiRNA-mediated Inhibition of Vascular Endothelial Growth Factor Severely Limits Tumor Resistance to Antiangiogenic Thrombospondin-1 and Slows Tumor Vascularization and Growth
Stephanie Filleur,Aurélie Courtin,Slimane Ait-Si-Ali,Julien Guglielmi,Carole Merle,Annick Harel-Bellan,Philippe Clézardin,Florence Cabon +7 more
TL;DR: Systemic in vivo administration of crude anti-VEGF siRNA reduced the growth of unaltered fibrosarcoma tumor cells, and was synergistic with the inhibitory effects derived from TSP1 secretion by the tumor cells themselves.