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Philippe Cupers
Researcher at Katholieke Universiteit Leuven
Publications - 8
Citations - 2809
Philippe Cupers is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Presenilin & Amyloid precursor protein. The author has an hindex of 5, co-authored 8 publications receiving 2724 citations. Previous affiliations of Philippe Cupers include Flanders Institute for Biotechnology.
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Journal ArticleDOI
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Bart De Strooper,Wim Annaert,Philippe Cupers,Paul Saftig,Katleen Craessaerts,Jeff S. Mumm,Eric H. Schroeter,Vincent Schrijvers,Michael S. Wolfe,William J. Ray,Alison Goate,Raphael Kopan +11 more
TL;DR: It is reported that, in mammalian cells, PS1 deficiency also reduces the proteolytic release of NICD from a truncated Notch construct, thus identifying the specific biochemical step of the Notch signalling pathway that is affected by PS1.
Journal ArticleDOI
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
An Herreman,Dieter H. Hartmann,Wim Annaert,Paul Saftig,Katleen Craessaerts,Lutgarde Serneels,Lieve Umans,Vincent Schrijvers,Frédéric Checler,Hugo Vanderstichele,Veerle Baekelandt,Ralf Dressel,Philippe Cupers,Danny Huylebroeck,An Zwijsen,Fred Van Leuven,Bart De Strooper +16 more
TL;DR: It is demonstrated in vivo that PS1 and PS2 have partially overlapping functions and thatPS1 is essential andPS2 is redundant for normal Notch signaling during mammalian embryological development.
Journal ArticleDOI
Interaction with Telencephalin and the Amyloid Precursor Protein Predicts a Ring Structure for Presenilins
Wim Annaert,Cary Esselens,Veerle Baert,C Boeve,Greet Snellings,Philippe Cupers,Katleen Craessaerts,Bart De Strooper +7 more
TL;DR: The authors' data surprisingly indicate a spatial dissociation between the binding site and the proposed catalytic site near the critical aspartates in PSs, which provides important experimental evidence to support a ring structure model for PS.
Journal ArticleDOI
Presenilin function in APP processing.
TL;DR: Familial Alzheimer's disease is now linked to at least three genes encoding the amyloid precursor protein (APP) on chromosome 21, and presenilin 1 and 2 on chromosome 14 and 1, respectively, and the cell biology of these proteins will be a rich source of insight into the pathology of AD, but will also shed light on the fundamental neurobiology ofThese proteins.