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Philippe Desprès
Researcher at University of La Réunion
Publications - 194
Citations - 15653
Philippe Desprès is an academic researcher from University of La Réunion. The author has contributed to research in topics: Virus & Flavivirus. The author has an hindex of 55, co-authored 184 publications receiving 14143 citations. Previous affiliations of Philippe Desprès include French Institute of Health and Medical Research & Institut de recherche pour le développement.
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Journal ArticleDOI
Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study
Van-Mai Cao-Lormeau,Alexandre Blake,Sandrine Mons,Stéphane Lastère,Claudine Roche,Jessica Vanhomwegen,Timothée Dub,Laure Baudouin,Anita Teissier,P. Larre,Anne-Laure Vial,Christophe Decam,Valérie Choumet,Susan K. Halstead,Hugh J. Willison,Lucile Musset,Jean-Claude Manuguerra,Philippe Desprès,Emmanuel Fournier,Henri-Pierre Mallet,Didier Musso,Arnaud Fontanet,Arnaud Fontanet,Jean Neil,Frédéric Ghawché +24 more
TL;DR: This is the first study providing evidence for Zika virus infection causing Guillain-Barré syndrome, and because Zika virus is spreading rapidly across the Americas, at risk countries need to prepare for adequate intensive care beds capacity to manage patients with Guillay-B Barré syndrome.
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Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak
Isabelle Schuffenecker,Isabelle Iteman,Alain Michault,Séverine Murri,Lionel Frangeul,Marie-Christine Vaney,Marie-Christine Vaney,Rachel Lavenir,Nathalie Pardigon,Jean-Marc Reynes,François Pettinelli,Leon Biscornet,Laure Diancourt,Stéphanie Michel,Stéphane Duquerroy,Stéphane Duquerroy,Stéphane Duquerroy,Ghislaine Guigon,Marie-Pascale Frenkiel,Anne-Claire Brehin,Nadège Cubito,Philippe Desprès,Frank Kunst,Félix A. Rey,Félix A. Rey,Hervé Zeller,Sylvain Brisse +26 more
TL;DR: The results indicate that the chikungunya virus outbreak was initiated by a strain related to East-African isolates, from which viral variants have evolved following a traceable microevolution history and may be due to adaptation to the mosquito vector.
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Biology of Zika Virus Infection in Human Skin Cells
Rodolphe Hamel,Ophélie Dejarnac,Sineewanlaya Wichit,Peeraya Ekchariyawat,Aymeric Neyret,Natthanej Luplertlop,Manuel Perera-Lecoin,Pornapat Surasombatpattana,Loïc Talignani,Frédéric Thomas,Van-Mai Cao-Lormeau,Valérie Choumet,Laurence Briant,Philippe Desprès,Ali Amara,Hans Yssel,Dorothée Missé +16 more
TL;DR: It is shown that human dermal fibroblasts, epidermal keratinocytes, and immature dendritic cells are permissive to the most recent ZikV isolate, responsible for the epidemic in French Polynesia, and a major role is shown for the phosphatidylserine receptor AXL as a ZIKV entry receptor and for cellular autophagy in enhancing ZIKv replication in permissive cells.
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Two Chikungunya isolates from the outbreak of La Reunion (Indian Ocean) exhibit different patterns of infection in the mosquito, Aedes albopictus.
Marie Vazeille,Sara Moutailler,D. Coudrier,Claudine Rousseaux,Huot Khun,Michel Huerre,Julien Thiria,Jean-Sébastien Dehecq,Didier Fontenille,Isabelle Schuffenecker,Philippe Desprès,Anna-Bella Failloux +11 more
TL;DR: The hypothesis that the CHIK outbreak in La Réunion Island was due to a highly competent vector Ae.
Journal ArticleDOI
A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease.
Thérèse Couderc,Fabrice Chrétien,Clémentine Schilte,Olivier Disson,Madly Brigitte,Florence Guivel-Benhassine,Yasmina Touret,G. Barau,Nadège Cayet,Isabelle Schuffenecker,Philippe Desprès,Fernando Arenzana-Seisdedos,Alain Michault,Matthew L. Albert,Marc Lecuit +14 more
TL;DR: It is shown that whereas wild type (WT) adult mice are resistant to CHIKV infection, WT mouse neonates are susceptible and neonatal disease severity is age-dependent, and the neonatal phase and inefficient type-I IFN signaling as risk factors for severe CHikV-associated disease are identified.