Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These

Phd by thesis

Microfabricated integrated circuits revolutionized computation by vastly reducing the space, labor, and time required for calculations. Microfluidic systems hold similar promise for the large-scale automation of chemistry and biology, suggesting the possibility of numerous experiments performed rapidly and in parallel, while consuming little reagent. While it is too early to tell whether such a vision will be realized, significant progress has been achieved, and various applications of significant scientific and practical interest have been developed. Here a review of the physics of small volumes (nanoliters) of fluids is presented, as parametrized by a series of dimensionless numbers expressing the relative importance of various physical phenomena. Specifically, this review explores the Reynolds number Re, addressing inertial effects; the Peclet number Pe, which concerns convective and diffusive transport; the capillary number Ca expressing the importance of interfacial tension; the Deborah, Weissenberg, and elasticity numbers De, Wi, and El, describing elastic effects due to deformable microstructural elements like polymers; the Grashof and Rayleigh numbers Gr and Ra, describing density-driven flows; and the Knudsen number, describing the importance of noncontinuum molecular effects. Furthermore, the long-range nature of viscous flows and the small device dimensions inherent in microfluidics mean that the influence of boundaries is typically significant. A variety of strategies have been developed to manipulate fluids by exploiting boundary effects; among these are electrokinetic effects, acoustic streaming, and fluid-structure interactions. The goal is to describe the physics behind the rich variety of fluid phenomena occurring on the nanoliter scale using simple scaling arguments, with the hopes of developing an intuitive sense for this occasionally counterintuitive world.

/pdf/microfluidics-fluid-physics-at-the-nanoliter-scale-4bpahtd8qa.pdf

Microfluidics: Fluid physics at the nanoliter scale

N G van Kampen 1981 Amsterdam: North-Holland xiv + 419 pp price Dfl 180 This is a book which, at a lower price, could be expected to become an essential part of the library of every physical scientist concerned with problems involving fluctuations and stochastic processes, as well as those who just enjoy a beautifully written book. It provides an extensive graduate-level introduction which is clear, cautious, interesting and readable.

https://iopscience.iop.org/article/10.1088/0031-9112/34/4/040/pdf

Stochastic Processes in Physics and Chemistry

基礎講座 電気泳動(Electrophoresis)

/pdf/degradable-controlled-release-polymers-and-polymeric-1y322ha58z.pdf

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

The ability of collapsing (cavitating) bubbles to focus and concentrate energy, forces and stresses is at the root of phenomena such as cavitation damage, sonochemistry or sonoluminescence1, 2. In a biomedical context, ultrasound-driven microbubbles have been used to enhance contrast in ultrasonic images3. The observation of bubble-enhanced sonoporation4, 5, 6?acoustically induced rupture of membranes?has also opened up intriguing possibilities for the therapeutic application of sonoporation as an alternative to cell-wall permeation techniques such as electroporation7 and particle guns8. However, these pioneering experiments have not been able to pinpoint the mechanism by which the violently collapsing bubble opens pores or larger holes in membranes. Here we present an experiment in which gentle (linear) bubble oscillations are sufficient to achieve rupture of lipid membranes. In this regime, the bubble dynamics and the ensuing sonoporation can be accurately controlled. The use of microbubbles as focusing agents makes acoustics on the micrometre scale (microacoustics) a viable tool, with possible applications in cell manipulation and cell-wall permeation as well as in microfluidic devices.

/pdf/controlled-vesicle-deformation-and-lysis-by-single-3j24gqiy7b.pdf

Controlled vesicle deformation and lysis by single oscillating bubbles

We depict and analyse the successive steps of atomization of a liquid jet when a fast gas stream blows parallel to its surface. Experiments performed with various liquids in a fast air flow show that the liquid destabilization proceeds from a two-stage mechanism: a shear instability first forms waves on the liquid. The transient acceleration experienced by the liquid suggests that a Rayleigh–Taylor type of instability is triggered at the wave crests, producing liquid ligaments which further stretch in the air stream and break into droplets.

On spray formation

We present a model applicable to ultrasound contrast agent bubbles that takes into account the physical properties of a lipid monolayer coating on a gas microbubble Three parameters describe the properties of the shell: a buckling radius, the compressibility of the shell, and a break-up shell tension The model presents an original non-linear behavior at large amplitude oscillations, termed compression-only, induced by the buckling of the lipid monolayer This prediction is validated by experimental recordings with the high-speed camera Brandaris 128, operated at several millions of frames per second The effect of aging, or the resultant of repeated acoustic pressure pulses on bubbles, is predicted by the model It corrects a flaw in the shell elasticity term previously used in the dynamical equation for coated bubbles The break-up is modeled by a critical shell tension above which gas is directly exposed to water

A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture

We present a model applicable to ultrasound contrast agent bubbles that takes into account the physical properties of a lipid monolayer coating on a gas microbubble. Three parameters describe the properties of the shell: a buckling radius, the compressibility of the shell, and a break-up shell tension. The model presents an original non-linear behavior at large amplitude oscillations, termed compression-only, induced by the buckling of the lipid monolayer. This prediction is validated by experimental recordings with the high-speed camera Brandaris 128, operated at several millions of frames per second. The effect of aging, or the resultant of repeated acoustic pressure pulses on bubbles, is predicted by the model. It corrects a flaw in the shell elasticity term previously used in the dynamical equation for coated bubbles. The break-up is modeled by a critical shell tension above which gas is directly exposed to water.

The formation of bubbles by flow focusing of a gas and a liquid in a rectangular channel is shown to depend strongly on the channel aspect ratio. Bubble breakup consists in a slow linear 2D collapse of the gas thread, ending in a fast 3D pinch-off. The 2D collapse is predicted to be stable against perturbations of the gas-liquid interface, whereas the 3D pinch-off is unstable, causing bubble polydispersity. During 3D pinch-off, a scaling wm~tau1/3 between the neck width wm and the time tau before breakup indicates that breakup is driven by the inertia of both gas and liquid, not by capillarity.

/pdf/role-of-the-channel-geometry-on-the-bubble-pinch-off-in-flow-4m12hkonmu.pdf

Philippe Marmottant

Papers

Controlled vesicle deformation and lysis by single oscillating bubbles

On spray formation

A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture

A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture

Role of the channel geometry on the bubble pinch-off in flow-focusing devices.