P
Philippe Robert
Researcher at Guerbet
Publications - 88
Citations - 3762
Philippe Robert is an academic researcher from Guerbet. The author has contributed to research in topics: Magnetic resonance imaging & Gadolinium. The author has an hindex of 27, co-authored 83 publications receiving 3428 citations.
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Recent advances in iron oxide nanocrystal technology for medical imaging
TL;DR: Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models.
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T1-Weighted Hypersignal in the Deep Cerebellar Nuclei After Repeated Administrations of Gadolinium-Based Contrast Agents in Healthy Rats: Difference Between Linear and Macrocyclic Agents.
Philippe Robert,Stéphane Lehéricy,Sylvie Grand,Xavier Violas,Nathalie Fretellier,Jean-Marc Idée,Sébastien Ballet,Claire Corot +7 more
TL;DR: In this article, the effect of multiple injections of macrocyclic (gadoterate meglumine) and linear gadolinium-based contrast agents (GBCAs) on T1-weighted signal intensity in the deep cerebellar nuclei (DCN) including the dentate nucleus was evaluated in healthy rats.
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Linear Gadolinium-Based Contrast Agents Are Associated With Brain Gadolinium Retention in Healthy Rats.
Philippe Robert,Xavier Violas,Sylvie Grand,Stéphane Lehéricy,Jean-Marc Idée,Sébastien Ballet,Claire Corot +6 more
TL;DR: Repeated administrations of the linear GBCAs gadodiamide, gadobenate dimeglumine, and gadopentetate dime glumine to healthy rats were associated with progressive and significant T1 signal hyperintensity in the DCN, along with Gd deposition in the cerebellum.
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Dynamic study of blood-brain barrier closure after its disruption using ultrasound: a quantitative analysis.
Benjamin Marty,Benoit Larrat,Benoit Larrat,Maxime Van Landeghem,Caroline Robic,Philippe Robert,Marc Port,Denis Le Bihan,Mathieu Pernot,Mickael Tanter,Franck Lethimonnier,Sébastien Mériaux +11 more
TL;DR: The model provides an invaluable basis for optimal design and delivery of nanoparticles to the brain and the maximum gap that may be safely generated between endothelial cells and the duration of opening of the BBB is studied.
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One-year Retention of Gadolinium in the Brain: Comparison of Gadodiamide and Gadoterate Meglumine in a Rodent Model.
Philippe Robert,Stefanie Fingerhut,Cécile Factor,Véronique Vives,Justine Letien,Michael R. Sperling,Marlène Rasschaert,Robin Santus,Sébastien Ballet,Jean-Marc Idée,Claire Corot,Uwe Karst +11 more
TL;DR: T1 hyperintensity of the deep cerebellar nuclei was observed only in gadodiamide-treated rats and remained stable from the 1st month after the last injection, while no T1 hyper intensity was observed with gadoterate, consistent with a rapid, time-dependent washout of the intact gadolinium chelate.