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Phillip A. Sharp
Researcher at Massachusetts Institute of Technology
Publications - 618
Citations - 125567
Phillip A. Sharp is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 172, co-authored 614 publications receiving 117126 citations. Previous affiliations of Phillip A. Sharp include McGovern Institute for Brain Research & Medical Research Council.
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Journal ArticleDOI
RNA-Mediated Feedback Control of Transcriptional Condensates.
Jonathan E. Henninger,Ozgur Oksuz,Krishna Shrinivas,Krishna Shrinivas,Ido Sagi,Gary LeRoy,Ming M. Zheng,J Owen Andrews,Alicia V. Zamudio,Charalampos Lazaris,Charalampos Lazaris,Nancy M. Hannett,Tong Ihn Lee,Phillip A. Sharp,Ibrahim I Cisse,Arup K. Chakraborty,Richard A. Young +16 more
TL;DR: Evidence from in-vitro and in vivo experiments support a model where RNAs produced during early steps in transcription initiation stimulate condensate formation, whereas the burst of RNAsproduced during elongation stimulate condensation.
Journal ArticleDOI
Target specificity of the CRISPR-Cas9 system
TL;DR: The CRISPR-Cas9 system, naturally a defense mechanism in prokaryotes, has been repurposed as an RNA-guided DNA targeting platform, and has shown great promise in correcting mutations in human genetic diseases.
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Five easy pieces
TL;DR: This is it the book that you can receive directly after purchasing, this five easy pieces is well known book in the world, of course many people will try to own it.
Journal ArticleDOI
Ultraspiracle: An invertebrate nuclear receptor for juvenile hormones
Grace Jones,Phillip A. Sharp +1 more
TL;DR: It is proposed that regulation of morphogenetic transitions in invertebrates involves binding of JH or JH-like structures to USP.
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Accurate cleavage and polyadenylation of exogenous RNA substrate.
Claire L. Moore,Phillip A. Sharp +1 more
TL;DR: Purified precursor RNA containing the L3polyadenylation site of late adenovirus 2 mRNA is accurately cleaved and polyadenylated when incubated with nuclear extract from HeLa cells, suggesting that processing is not coupled to the synthesis of the initial poly(A) tract.