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Phillip A. Sharp
Researcher at Massachusetts Institute of Technology
Publications - 618
Citations - 125567
Phillip A. Sharp is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 172, co-authored 614 publications receiving 117126 citations. Previous affiliations of Phillip A. Sharp include McGovern Institute for Brain Research & Medical Research Council.
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Journal ArticleDOI
A coactivator of pre-mrna splicing
TL;DR: The results suggest that a complex of the nuclear matrix proteins SRm160 and SRm300 functions as a coactivator of pre-mRNA splicing.
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Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression
TL;DR: Knockdown of pyruvate kinase M2 induces apoptosis and tumor regression of multiple cancer types and is associated with death in several cancer types.
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Messenger RNA splicing in vitro: An excised intervening sequence and a potential intermediate
TL;DR: Results suggest that the splicing of mRNA precursors may involve sites in the intervening sequence, cleavage at the 5' splice site, cleaving at the 3' splicing site, and ligation of the two exons.
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14-3-3σ controls mitotic translation to facilitate cytokinesis
Erik W. Wilker,Marcel A. T. M. van Vugt,Stephen C. Artim,Paul H. Huang,Christian P. Petersen,H. Christian Reinhardt,Yun Feng,Phillip A. Sharp,Nahum Sonenberg,Forest M. White,Michael B. Yaffe +10 more
TL;DR: A previously unknown function for 14-3-3σ is reported as a regulator of mitotic translation through its direct mitosis-specific binding to a variety of translation/initiation factors, including eukaryotic initiation factor 4B in a stoichiometric manner.
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Specific binding of a basic peptide from HIV-1 Rev.
TL;DR: In this article, a 17 amino acid peptide, corresponding to the basic domain of the Rev protein, was found to bind specifically to this site at essentially identical nucleotides and probably induces additional base pairing.