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Phillip A. Sharp
Researcher at Massachusetts Institute of Technology
Publications - 618
Citations - 125567
Phillip A. Sharp is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 172, co-authored 614 publications receiving 117126 citations. Previous affiliations of Phillip A. Sharp include McGovern Institute for Brain Research & Medical Research Council.
Papers
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Journal ArticleDOI
Novel mechanism and factor for regulation by HIV-1 Tat.
Qiang Zhou,Phillip A. Sharp +1 more
TL;DR: Tat acts through a novel mechanism, which is mediated by a specific host cellular factor, to stimulate HIV‐1 gene expression, and while TATA binding protein (TBP)‐associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, they are dispensable for Tat function.
Journal ArticleDOI
The infectivity of adenovirus 5 DNA-protein complex.
TL;DR: Adenovirus 5 DNA-protein complexes were prepared by treating virions with 4 M guanidinium chloride and resolving the faster sedimenting viral DNA from released capsid protein and characterized by both gel electrophoresis and electron microscopy.
Patent
Nuclear factors associated with transcriptional regulation
David Baltimore,Ranjan Sen,Phillip A. Sharp,Harinder Singh,Louis M. Staudt,Jonathan H. LeBowitz,Albert S. Baldwin,Roger G. Clerc,Lynn M. Corcoran,Patrick A. Baeuerle,Michael J. Lenardo,Chen-Ming Fan,Thomas P. Maniatis +12 more
TL;DR: In this paper, constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are identified and isolated by an improved assay for protein-DNA binding.
Journal ArticleDOI
A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes.
TL;DR: Interestingly, expression of MBP-1 mRNA was inducible by mitogen and phorbol ester treatment of Jurkat T cells and by serum treatment of confluent serum-deprived human fibroblasts, with relatively high expression in HeLa cells and in a human retinal cell line.
Journal ArticleDOI
Three recognition events at the branch-site adenine
TL;DR: The chemical groups on the adenine base at the branch site are differentially recognized during at least three different processes in the splicing of pre‐mRNA.