P
Phillip A. Sharp
Researcher at Massachusetts Institute of Technology
Publications - 618
Citations - 125567
Phillip A. Sharp is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 172, co-authored 614 publications receiving 117126 citations. Previous affiliations of Phillip A. Sharp include McGovern Institute for Brain Research & Medical Research Council.
Papers
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Journal ArticleDOI
Large T antigens of simian virus 40 and polyomavirus efficiently establish primary fibroblasts.
P S Jat,Phillip A. Sharp +1 more
TL;DR: In this paper, retroviruses that transduce the simian virus 40 (SV40) large T antigen or the polyomavirus large t antigen as well as encoding resistance to antibiotic G418 were used to investigate whether these genes alone were sufficient for immortalization of primary cells.
Journal ArticleDOI
A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription.
Tomi P. Mäkelä,Jeffrey D. Parvin,Jeffrey D. Parvin,Jaesang Kim,L. J. Huber,Phillip A. Sharp,Robert A. Weinberg +6 more
TL;DR: TFIIH preparations containing mutant, kinase-deficient MO15 lack CTD kinase activity, indicating that MO15 is critical for polymerase phosphorylation, but results indicate that CTDosphorylation is not required for transcription with a highly purified system.
Journal ArticleDOI
The SRm160/300 splicing coactivator subunits.
Benjamin J. Blencowe,Göran Baurén,Adam G. Eldridge,Robbyn Issner,Jeffrey A. Nickerson,Emanuel Rosonina,Phillip A. Sharp +6 more
TL;DR: The results indicate that SRm160 may be the more critical component of theSRm160/300 coactivator in the splicing of SRm 160/300-dependent pre-mRNAs, and the isolation of a cDNA encoding the 300-kDa antigen is reported.
Patent
Chimeric DNA-binding proteins
TL;DR: Chimeric proteins containing composite DNA-binding regions are disclosed together with DNA constructs encoding them, compositions containing them and applications in which they are useful in this paper, together with their applications.