Phillip A. Sharp

TL;DR: Results suggest that high-dose supplements might not be the most efficient way of increasing the body pool of vitamin C.

TL;DR: In this article, an approach to characterizing miRNA-regulatory networks by systematically profiling transcriptional, post-transcriptional and epigenetic activity in a pair of isogenic murine fibroblast cell lines with and without Dicer expression is described.

TL;DR: The data suggests that Dcytb plays a physiological role in both iron and copper uptake, through divalent metal transporter 1 (DMT1) and copper transporter 1, respectively, and shows that 59Fe uptake was significantly enhanced in D Cytb‐EGFP expressing MDCK cells which endogenously express DMT1.

TL;DR: The in vivo administration of siRNA to Parp1 in mouse models of ovarian cancer extends the survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells but not from BrCA1 wild-type cells, confirming the proposed mechanism of synthetic lethality.

TL;DR: It is reported that U1 snRNP recognition and transcription pausing at stable nucleosomes are linked through premature polyadenylation signal (PAS) termination, and it is proposed that premature PAS termination near the nucleosome-associated pause site represents a common transcriptional elongation checkpoint regulated by U1 snR NP recognition, nucleosom stability, and Myc activity.