P
Phillip A. Sharp
Researcher at Massachusetts Institute of Technology
Publications - 618
Citations - 125567
Phillip A. Sharp is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 172, co-authored 614 publications receiving 117126 citations. Previous affiliations of Phillip A. Sharp include McGovern Institute for Brain Research & Medical Research Council.
Papers
More filters
Journal ArticleDOI
In vitro transcription of adenovirus.
TL;DR: Microheterogeneity of 5' termini at several adenovirus promoters, previously shown in vivo, was reproduced in the in vitro reaction and indeed appeared to result from heterogeneous initiation rather than 5' processing.
Journal ArticleDOI
Adenovirus recombination: Physical mapping of crossover events
TL;DR: Recombinants have been isolated from crosses of temperature-sensitive mutants of two adenovirus serotypes whose DNAs differ in their cleavage patterns with restricting endonucleases, and from the results one can align the adanovirus genetic and physical maps.
Journal ArticleDOI
Localization of a repressive sequence contributing to B-cell specificity in the immunoglobulin heavy-chain enhancer.
TL;DR: In this paper, the presence of a dominant repressor element within the mu enhancer was found to activate transcription in fibroblasts but not in myeloma cells, and the possible biological roles of this phenomenon were discussed.
Journal ArticleDOI
Analysis of homeodomain function by structure-based design of a transcription factor
TL;DR: Results prove that the Oct-1 homeodomain mediates all the protein-protein interactions that are required to efficiently recruit alpha-transinduction factor and C1 factor into a C1 complex.
Journal ArticleDOI
Detection of a homologous series of C26-C38 polyenoic fatty acids in the brain of patients without peroxisomes (Zellweger's syndrome).
TL;DR: The brains of patients with inherited abnormalities in peroxisomal structure and function contain greatly increased proportions of a homologous series of unique polyenoic fatty acids with carbon chain lengths ranging from 26 to 38 according to evidence by chemical ionization and electron impact mass spectrometry.