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Phillip A. Sharp
Researcher at Massachusetts Institute of Technology
Publications - 618
Citations - 125567
Phillip A. Sharp is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 172, co-authored 614 publications receiving 117126 citations. Previous affiliations of Phillip A. Sharp include McGovern Institute for Brain Research & Medical Research Council.
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Rna sequence-specific mediators of rna interference
TL;DR: In this paper, a Drosophila in vitro system was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length.
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siRNA-directed inhibition of HIV-1 infection.
Carl D. Novina,Michael F. Murray,Derek M. Dykxhoorn,Paul J. Beresford,Jonathan W. Riess,Sang-Kyung Lee,Ronald G. Collman,Judy Lieberman,Premlata Shankar,Phillip A. Sharp +9 more
TL;DR: It is reported that siRNAs inhibit virus production by targeting the mRNAs for either the HIV-1 cellular receptor CD4, the viral structural Gag protein or green fluorescence protein substituted for the Nef regulatory protein.
Journal ArticleDOI
Short RNAs Repress Translation after Initiation in Mammalian Cells
TL;DR: Results suggest that repression by short RNAs, and thus probably miRNAs, is primarily due to ribosome drop off during elongation of translation.
Journal ArticleDOI
RNA interference—2001
TL;DR: Genetic studies have expanded the biology of RNAi to cosuppression, transposon silencing, and the first hints of relationships to regulation of translation and development, as well as expanding the possible roles of RNA-dependent RNA polymerase (RdRp) in RNAi.
Journal ArticleDOI
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis
Sidi Chen,Sidi Chen,Neville E. Sanjana,Kaijie Zheng,Ophir Shalem,Kyungheon Lee,Xi Shi,David A. Scott,Jun S. Song,Jen Q. Pan,Ralph Weissleder,Hakho Lee,Feng Zhang,Phillip A. Sharp +13 more
TL;DR: In this paper, a genome-wide CRISPR/Cas9-mediated loss-of-function screen in tumor growth and metastasis was described. But the authors focused on the effect of mutations on primary tumor growth positively correlates with the development of metastases.