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Phillip A. Sharp
Researcher at Massachusetts Institute of Technology
Publications - 618
Citations - 125567
Phillip A. Sharp is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 172, co-authored 614 publications receiving 117126 citations. Previous affiliations of Phillip A. Sharp include McGovern Institute for Brain Research & Medical Research Council.
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Journal ArticleDOI
Regulation of jejunal glucose transporter expression by forskolin.
Mark Williams,Phillip A. Sharp +1 more
TL;DR: The effects of forskolin on enterocyte membrane expression of the glucose transporters, SGLT1 and GLUT2, which are thought to be the main entry and efflux pathways for glucose, respectively, are investigated and the implications for glucose transport are discussed.
Journal ArticleDOI
Transferrin receptor 2 is crucial for iron sensing in human hepatocytes
Chiara Rapisarda,Juliana Puppi,Robin D. Hughes,Anil Dhawan,Sebastien Farnaud,Sebastien Farnaud,Robert W. Evans,Phillip A. Sharp +7 more
TL;DR: The data suggest that transferrin receptor 2 is a likely candidate to explain the differences in iron sensing between hepatoma cell lines and primary human hepatocytes.
Journal ArticleDOI
Meeting global challenges: Discovery and innovation through convergence
TL;DR: In this paper, the authors discuss the history of the transition from discovery to innovation at the molecular level in life sciences and discuss how further convergence of physical, mathematical, engineering, and social sciences with life sciences will accelerate innovation.
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Pea Ferritin Stability under Gastric pH Conditions Determines the Mechanism of Iron Uptake in Caco-2 Cells
Antonio Perfecto,Ildefonso Rodríguez-Ramiro,Jorge Rodríguez-Celma,Jorge Rodríguez-Celma,Phillip A. Sharp,Janneke Balk,Janneke Balk,Susan J. Fairweather-Tait +7 more
TL;DR: In this paper, the potential of purified ferritin from peas (Pisum sativum) as a food supplement was examined by measuring its stability under gastric pH treatment and the mechanisms of iron uptake into Caco-2 cells.
Journal ArticleDOI
Isolation of catenated forms of R factor DNA from minicells.
TL;DR: In selecting for covalently circular R factor DNA molecules, the procedures used in these earlier experiments-caesium chloride-ethidium bromide centrifuga-tion7 and bulk nitrocellulose adsorption2—necessarily selected against isolation of other (non-circular) forms of R factorDNA that might have been present.