P
Phillip Scott
Researcher at University of Pennsylvania
Publications - 182
Citations - 17429
Phillip Scott is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Leishmania major & Immune system. The author has an hindex of 68, co-authored 176 publications receiving 16477 citations. Previous affiliations of Phillip Scott include University of Maryland, Baltimore & Wistar Institute.
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Journal ArticleDOI
Leishmaniasis: complexity at the host–pathogen interface
Paul M. Kaye,Phillip Scott +1 more
TL;DR: Recent evidence suggests that each host–pathogen combination evokes different solutions to the problems of parasite establishment, survival and persistence in Leishmania spp.
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Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.
TL;DR: It is demonstrated that a T cell line established against fraction 9, designated line 9, transfers protection equivalent to that obtained by active immunization, and suggested that susceptibility and resistance in experimental leishmaniasis may depend upon a balance between the Th subsets induced.
Journal ArticleDOI
The adjuvant effect of interleukin-12 in a vaccine against Leishmania major
Luís Carlos Crocco Afonso,Tanya M. Scharton,Leda Quercia Vieira,Maria Wysocka,Giorgio Trinchieri,Phillip Scott +5 more
TL;DR: IL-12 is an effective adjuvant for the initiation of protective cell- mediated immunity against leishmaniasis and may be an important component in other vaccines that need to induce cell-mediated immunity.
Journal ArticleDOI
Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice.
Tanya M. Scharton,Phillip Scott +1 more
TL;DR: Data indicate that the stimulation of NK cells, through the production of IFN-gamma, plays an important role in initiating Th1 cell differentiation in leishmaniasis and in controlling early resistance to L. major.