P
Pier Paolo Pandolfi
Researcher at Beth Israel Deaconess Medical Center
Publications - 537
Citations - 97848
Pier Paolo Pandolfi is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: PTEN & Promyelocytic leukemia protein. The author has an hindex of 146, co-authored 529 publications receiving 88334 citations. Previous affiliations of Pier Paolo Pandolfi include Ohio State University & Saitama Medical University.
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A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
TL;DR: It is proposed that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.
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The multilayered complexity of ceRNA crosstalk and competition
TL;DR: Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.
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A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
Laura Poliseno,Leonardo Salmena,Jiangwen Zhang,Brett S. Carver,William J. Haveman,Pier Paolo Pandolfi +5 more
TL;DR: It is found that PTENP1 is biologically active as it can regulate cellular levels of PTEN and exert a growth-suppressive role, and this analysis extended to other cancer-related genes that possess pseudogenes, and revealed a non-coding function for mRNAs.
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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Zhenbang Chen,Lloyd C. Trotman,David R. Shaffer,Hui Kuan Lin,Zohar A. Dotan,Masaru Niki,Jason A. Koutcher,Howard I. Scher,Thomas Ludwig,William L. Gerald,Carlos Cordon-Cardo,Pier Paolo Pandolfi +11 more
TL;DR: It is shown that conditional inactivation of Trp53 in the mouse prostate fails to produce a tumour phenotype, whereas complete Pten inactivation in the prostate triggers non-lethal invasive prostate cancer after long latency, and support a model for cooperative tumour suppression in which p53 is an essential failsafe protein of Pten-deficient tumours.
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The p66shc adaptor protein controls oxidative stress response and life span in mammals
Enrica Migliaccio,Marco Giorgio,Simonetta Mele,Giuliana Pelicci,Paolo Reboldi,Pier Paolo Pandolfi,Luisa Lanfrancone,Pier Giuseppe Pelicci,Pier Giuseppe Pelicci +8 more
TL;DR: It is proposed that p66shc is part of a signal transduction pathway that regulates stress apoptotic responses and life span in mammals.