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Pierre Farmer
Researcher at Swiss Institute of Bioinformatics
Publications - 14
Citations - 5218
Pierre Farmer is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 10, co-authored 14 publications receiving 4878 citations. Previous affiliations of Pierre Farmer include Merck Serono & École Polytechnique Fédérale de Lausanne.
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Journal ArticleDOI
Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis
Christos Sotiriou,Pratyaksha Wirapati,Sherene Loi,Adrian L. Harris,Steve Fox,Johanna Smeds,Hans Nordgren,Pierre Farmer,Viviane Praz,Benjamin Haibe-Kains,Christine Desmedt,Denis Larsimont,Fatima Cardoso,Hans Peterse,Dimitry S.A. Nuyten,Marc Buyse,Marc J. van de Vijver,Jonas Bergh,Martine Piccart,Mauro Delorenzi +19 more
TL;DR: Gene expression grade index appeared to reclassify patients with histologic grade 2 tumors into two groups with high versus low risks of recurrence, which may improve the accuracy of tumor grading and thus its prognostic value.
Journal ArticleDOI
Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures
Pratyaksha Wirapati,Christos Sotiriou,Susanne Kunkel,Pierre Farmer,Sylvain Pradervand,Benjamin Haibe-Kains,Christine Desmedt,Michail Ignatiadis,Thierry Sengstag,Frédéric Schütz,Darlene R. Goldstein,Darlene R. Goldstein,Darlene R. Goldstein,Martine Piccart,Mauro Delorenzi +14 more
TL;DR: This meta-analysis of publicly available breast cancer gene expression and clinical data reveals connections between traditional prognostic factors, expression-based subtyping, and prognostic signatures, highlighting the important role of proliferation in breast cancer prognosis.
Journal ArticleDOI
Identification of molecular apocrine breast tumours by microarray analysis
Pierre Farmer,Hervé Bonnefoi,Véronique Becette,Michèle Tubiana-Hulin,Pierre Fumoleau,Denis Larsimont,Gaëtan MacGrogan,Jonas Bergh,David Cameron,Darlene R. Goldstein,Darlene R. Goldstein,Stephan Duss,Anne-Laure Nicoulaz,Cathrin Brisken,Maryse Fiche,Mauro Delorenzi,Mauro Delorenzi,Richard Iggo +17 more
TL;DR: The identification of a group of breast tumours with increased androgen signalling and a ‘molecular apocrine’ gene expression profile is reported, suggesting that molecular apocrine tumours represent 8–14% of tumours in four published breast cancer studies.
Journal ArticleDOI
A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
Pierre Farmer,Pierre Farmer,Pierre Farmer,Hervé Bonnefoi,Pascale Anderle,David Cameron,David Cameron,Pratyakasha Wirapati,Véronique Becette,Sylvie André,Martine Piccart,Mario Campone,Etienne Brain,Gaëtan MacGrogan,Thierry Petit,Jacek Jassem,Frédéric Bibeau,Emmanuel Blot,Jan Bogaerts,Michel Aguet,Jonas Bergh,Richard Iggo,Richard Iggo,Mauro Delorenzi,Mauro Delorenzi +24 more
TL;DR: It is reported that increased stromal gene expression predicts resistance to preoperative chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC) in subjects in the EORTC 10994/BIG 00-01 trial and suggests that antistromal agents may offer new ways to overcome resistance to chemotherapy.
Journal ArticleDOI
Identification of molecular apocrine breast tumours by microarray analysis
Pierre Farmer,H Bonnefoi,Véronique Becette,Michèle Tubiana-Hulin,Pierre Fumoleau,Denis Larsimont,Gaëtan MacGrogan,Jonas Bergh,David Cameron,Darlene R. Goldstein,Stephan Duss,A-L Nicoulaz,Maryse Fiche,Cathrin Brisken,Mauro Delorenzi,Richard Iggo +15 more
TL;DR: The identification of a group of breast tumours with increased androgen signalling and a 'molecular apocrine' gene expression profile is reported, suggesting that molecular apocrine tumours represent 8–14% of tumours in four published breast cancer studies.