P
Pierre Vanderhaeghen
Researcher at Université libre de Bruxelles
Publications - 99
Citations - 8945
Pierre Vanderhaeghen is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Neurogenesis & Induced pluripotent stem cell. The author has an hindex of 47, co-authored 91 publications receiving 7956 citations. Previous affiliations of Pierre Vanderhaeghen include Free University of Brussels & Karolinska Institutet.
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Journal ArticleDOI
The ephrins and eph receptors in neural development
TL;DR: The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps, and may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system.
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An RNA gene expressed during cortical development evolved rapidly in humans
Katherine S. Pollard,Sofie R. Salama,Nelle Lambert,Marie-Alexandra H. Lambot,Sandra Coppens,Jakob Skou Pedersen,Sol Katzman,Bryan King,Courtney Onodera,Adam Siepel,Andrew D. Kern,Colette Dehay,Haller Igel,Haller Igel,Manuel Ares,Manuel Ares,Pierre Vanderhaeghen,David Haussler +17 more
TL;DR: The most dramatic of these ‘human accelerated regions’, HAR1, is part of a novel RNA gene (HAR1F) that is expressed specifically in Cajal–Retzius neurons in the developing human neocortex from 7 to 19 gestational weeks, a crucial period for cortical neuron specification and migration.
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An intrinsic mechanism of corticogenesis from embryonic stem cells
Nicolas Gaspard,Tristan Bouschet,Raphael Hourez,Jordane Dimidschstein,Gilles Naeije,Jelle van den Ameele,Ira Espuny-Camacho,Adèle Herpoel,Lara Passante,Serge N. Schiffmann,Afsaneh Gaillard,Pierre Vanderhaeghen +11 more
TL;DR: It is shown that mouse embryonic stem cells, cultured without any morphogen but in the presence of a sonic hedgehog inhibitor, recapitulate in vitro the major milestones of cortical development, leading to the sequential generation of a diverse repertoire of neurons that display most salient features of genuine cortical pyramidal neurons.
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Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo.
Ira Espuny-Camacho,Kimmo A. Michelsen,David Gall,Daniele Linaro,Anja Hasche,Jérôme Bonnefont,Camilia Bali,David Orduz,Angéline Bilheu,Adèle Herpoel,Nelle Lambert,Nicolas Gaspard,Sophie Péron,Serge N. Schiffmann,Michele Giugliano,Michele Giugliano,Michele Giugliano,Afsaneh Gaillard,Pierre Vanderhaeghen +18 more
TL;DR: The data demonstrate that human cortical neurons generated in vitro from ESC/iPSC can develop complex hodological properties characteristic of the cerebral cortex in vivo, thereby offering unprecedented opportunities for the modeling of human cortex diseases and brain repair.
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Inhibition of SRGAP2 Function by Its Human-Specific Paralogs Induces Neoteny during Spine Maturation
Cécile Charrier,Kaumudi Joshi,Jaeda Coutinho-Budd,Jieun Kim,Nelle Lambert,Jacqueline de Marchena,Weilin Jin,Pierre Vanderhaeghen,Anirvan Ghosh,Takayuki Sassa,Franck Polleux +10 more
TL;DR: The results suggest that inhibition of SRGAP2 function by its human-specific paralogs has contributed to the evolution of the human neocortex and plays an important role during human brain development.