Author
Piet van Zoonen
Bio: Piet van Zoonen is an academic researcher. The author has contributed to research in topics: Gas chromatography & Thermospray. The author has an hindex of 9, co-authored 10 publications receiving 607 citations.
Papers
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TL;DR: The role of gas chromatography as an analytical tool in combination with currently used or recently developed sample preparation techniques is described.
228 citations
TL;DR: Until recently, the application of liquid chromatography in pesticide analysis was usually focused on groups of compounds or single compounds for which no suitable conditions were available for analysis with gas chromatography (GC), but recent developments in both detection and column material technology show that LC significantly enlarged its scope in this field of analysis.
159 citations
TL;DR: The adopted LC/LC-TSP/MS/ MS analyzer appeared to be very robust under the selected conditions, and, after the period of analysis involving the processing of more than 100 mL of serum, neither loss of chromatographic performance nor pressure increase of columns or of the interface was observed.
Abstract: This study investigated the potential of restricted access media (RAM) columns used as a first column in coupled-column LC hyphenated to thermospray tandem mass spectrometry (LC/LC−TSP/MS/MS) for the fast, selective, and sensitive determination of target drugs in serum samples. Because of their wide range in polarity, salbutamol and clenbuterol were chosen as model compounds and representatives of the class of β2-agonists. Three types of RAM columns were tested: (i) Pinkerton ISRP (internal surface reversed phase, 5 μm), (ii) SPS (semipermeable surface, 5 μm C18), and (iii) RP-18 ADS (alkyl-diol silica, 25 μm). A 3-μm C18 column (50 mm × 4.6 mm i.d.) was chosen as the second column. Tandem mass spectrometric detection was carried out in the selected reaction monitoring (one parent→one daughter) mode. With regard to retention and, moreover, the peak elution volume of the analytes, the ISRP material was found to perform best: a 50-mm × 4.6-mm i.d. ISRP column in combination with a 100% aqueous buffer (pH ...
59 citations
TL;DR: In this article, the ASPEC system was coupled with capillary GC-ECD by means of a loop-type interface equipped with a solvent vapour exit, leading to an effective clean-up of the extracts analyzed.
Abstract: The ASPEC (Automatic Sample Preparation with Extraction Columns) system has been coupled on-line to capillary GC-ECD by means of a loop-type interface equipped with a solvent vapour exit. Both ASPEC and GC conditions have been optimized leading to an effective clean-up of the extracts analyzed.
By means of solid-phase extraction cartridges filled with silica, it has been possible to analyze concentrated surface water extracts for a group of 18 electron-capturing compounds present in the water at ppt levels. ASPEC-GC has also been applied to the determination of synthetic pyrethroids at ppt levels in surface water.
The complete analytical procedure is greatly facilitated by automation and miniaturization. Miniaturization results in a considerable decrease in the sample volume required. The potential of the method for the analysis of other pesticides is estimated.
49 citations
TL;DR: In this article, micro liquid-liquid extraction with methyl tert-butyl ether was combined with GC-FPD in a fully automated set-up, using GC sample introduction volumes of 500 μl, which were transferred via an oncolumn interface equipped with an early vapour exit.
40 citations
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TL;DR: The objective of this review is to provide updated information about the most important features of the new solid-phase extraction (SPE) materials, their interaction mode and their potential for modern SPE.
975 citations
TL;DR: Agarwal et al. as mentioned in this paper proposed a computer-aided method development approach to replace tedious trial-and-error procedures with fast simulations based on suitable kinetic and retention models.
Abstract: Solid-phase extraction using cartridge and disc devices is a widely used sample-preparation technique for isolation, concentration, clean-up and medium exchange. To meet the varied needs of contemporary applications, there is available an ever-increasing range of sorbent chemistries based on inorganic oxides, low-specificity (chemically bonded, porous polymer and carbon) and compound and group-selective (ion exchange, mixed mode, macrocyclic, restricted access, immunoaffinity and molecularly imprinted polymer) materials. Advanced device formats facilitate processing of problem samples combined with a high level of automation. Approaches to computer-aided method development promise to replace tedious trial-and-error procedures with fast simulations based on suitable kinetic and retention models.
624 citations
602 citations
TL;DR: The results indicated that both ionization types showed matrix effect, but ESI was more susceptible than APCI, while SPE was necessary for extensive clean up of plasma prior to LC-APCI-MS/MS.
566 citations
TL;DR: The principles of stir bar sorptive extraction are described and an overview of SBSE applications is given, as illustrated by several successful applications in trace analysis in environmental, food and biomedical fields.
451 citations