P
Pieter Van Vlierberghe
Researcher at Ghent University
Publications - 155
Citations - 9304
Pieter Van Vlierberghe is an academic researcher from Ghent University. The author has contributed to research in topics: Leukemia & T cell. The author has an hindex of 35, co-authored 129 publications receiving 7754 citations. Previous affiliations of Pieter Van Vlierberghe include Erasmus University Rotterdam & Ghent University Hospital.
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Journal ArticleDOI
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
Jay P. Patel,Mithat Gonen,Maria E. Figueroa,Hugo Fernandez,Zhuoxin Sun,Janis Racevskis,Pieter Van Vlierberghe,Igor Dolgalev,Sabrena Thomas,Olga Aminova,Kety Huberman,Janice Cheng,Agnes Viale,Nicholas D. Socci,Adriana Heguy,Athena M. Cherry,Gail H. Vance,Rodney R. Higgins,Rhett P. Ketterling,Robert E. Gallagher,Mark R. Litzow,Marcel R.M. van den Brink,Hillard M. Lazarus,Jacob M. Rowe,Selina M. Luger,Adolfo A. Ferrando,Elisabeth Paietta,Martin S. Tallman,Ari Melnick,Omar Abdel-Wahab,Ross L. Levine +30 more
TL;DR: Genetic predictors of outcome that improved risk stratification among patients with AML, independently of age, white-cell count, induction dose, and post-remission therapy, are identified and the significance of these predictors in an independent cohort is validated.
Journal ArticleDOI
A novel and universal method for microRNA RT-qPCR data normalization
Pieter Mestdagh,Pieter Van Vlierberghe,An-Sofie De Weer,Daniel Muth,Frank Westermann,Frank Speleman,Jo Vandesompele +6 more
TL;DR: It is demonstrated that the mean expression value outperforms the current normalization strategy in terms of better reduction of technical variation and more accurate appreciation of biological changes.
Journal ArticleDOI
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
Panagiotis Ntziachristos,Panagiotis Ntziachristos,Aristotelis Tsirigos,Pieter Van Vlierberghe,Jelena Nedjic,Thomas Trimarchi,Maria Sol Flaherty,Dolors Ferres-Marco,Vanina Gabriela Da Ros,Zuojian Tang,Jasmin M. Siegle,Patrik Asp,Michael Hadler,Isaura Rigo,Kim De Keersmaecker,Kim De Keersmaecker,Jay P. Patel,Tien Huynh,Filippo Utro,Sandrine Poglio,Jeremy B. Samon,Elisabeth Paietta,Janis Racevskis,Jacob M. Rowe,Raul Rabadan,Ross L. Levine,Stuart M. Brown,Françoise Pflumio,Maria Dominguez,Adolfo A. Ferrando,Iannis Aifantis +30 more
TL;DR: It is demonstrated that activation of NOTCH1 specifically induces loss of the repressive mark lysine-27 tri-methylation of histone 3 (H3K27me3)4 by antagonizing the activity of the Polycomb Repressive Complex 2 (PRC2) complex.
Journal ArticleDOI
The molecular basis of T cell acute lymphoblastic leukemia
TL;DR: This review summarizes recent advances in the understanding of the molecular genetics of T-ALL and defines distinct molecular groups ofT-ALL with specific gene expression signatures and clinicobiological features.
Journal ArticleDOI
Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia
Irene Homminga,Rob Pieters,Anton W. Langerak,Johan J. de Rooi,Andrew P. Stubbs,Monique Verstegen,Maartje Vuerhard,Jessica Buijs-Gladdines,Clarissa Kooi,Petra Klous,Petra Klous,Pieter Van Vlierberghe,Adolfo A. Ferrando,Jean Michel Cayuela,Brenda Verhaaf,H. Berna Beverloo,Martin A. Horstmann,Valerie de Haas,Anna-Sophia Wiekmeijer,Karin Pike-Overzet,Frank J. T. Staal,Wouter de Laat,Wouter de Laat,Jean Soulier,François Sigaux,Jules P.P. Meijerink +25 more
TL;DR: NKX2-1, NKX22-2, and MEF2C are proposed as T-ALL oncogenes that are activated by various rearrangements.