P
Pinar Ayata
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 17
Citations - 2483
Pinar Ayata is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Microglia & Gene. The author has an hindex of 10, co-authored 16 publications receiving 1785 citations. Previous affiliations of Pinar Ayata include Howard Hughes Medical Institute & Rockefeller University.
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Journal ArticleDOI
MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System
TL;DR: It is reported that 5hmC is enriched in active genes and that, surprisingly, strong depletion of 5mC is observed over these regions and these findings support a model in which5hmC and MeCP2 constitute a cell-specific epigenetic mechanism for regulation of chromatin structure and gene expression.
Journal ArticleDOI
MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system
TL;DR: In this paper, a quantitative, genome-wide analysis of 5hmC, 5-methylcytosine (5mC), and gene expression in differentiated CNS cell types in vivo is presented.
Journal ArticleDOI
Negative feedback control of neuronal activity by microglia
Ana Badimon,Hayley J. Strasburger,Pinar Ayata,Xinhong Chen,Aditya Nair,Ako Ikegami,Ako Ikegami,Philip Hwang,Andrew T. Chan,Steven M. Graves,Joseph O. Uweru,Carola Ledderose,Munir Gunes Kutlu,Michael A. Wheeler,Anat Kahan,Masago Ishikawa,Ying-Chih Wang,Yong-Hwee E. Loh,Jean X. Jiang,D. James Surmeier,Simon C. Robson,Wolfgang G. Junger,Robert Sebra,Erin S. Calipari,Paul J. Kenny,Ukpong B. Eyo,Marco Colonna,Francisco J. Quintana,Francisco J. Quintana,Hiroaki Wake,Hiroaki Wake,Viviana Gradinaru,Anne Schaefer +32 more
TL;DR: It is suggested that this microglia-driven negative feedback mechanism operates similarly to inhibitory neurons and is essential for protecting the brain from excessive activation in health and disease.
Journal ArticleDOI
Epigenetic regulation of brain region-specific microglia clearance activity
Pinar Ayata,Ana Badimon,Hayley J. Strasburger,Mary Kaye Duff,Sarah E. Montgomery,Yong-Hwee E. Loh,Anja Ebert,Anna A. Pimenova,Brianna R. Ramirez,Andrew T. Chan,Josefa M. Sullivan,Immanuel Purushothaman,Joseph R. Scarpa,Alison Goate,Meinrad Busslinger,Li Shen,Bojan Losic,Anne Schaefer +17 more
TL;DR: It is shown that microglia clearance activity in the adult brain is regionally regulated and depends on the rate of neuronal attrition, which highlights a key role of epigenetic mechanisms in preventing microglian-induced neuronal alterations that are frequently associated with neurodegenerative and psychiatric diseases.
Journal ArticleDOI
Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling.
Georgia Gunner,Lucas Cheadle,Kasey M. Johnson,Pinar Ayata,Ana Badimon,Erica Mondo,M. Aurel Nagy,Liwang Liu,Shane M. Bemiller,Ki-Wook Kim,Sergio A. Lira,Bruce T. Lamb,Andrew R. Tapper,Richard M. Ransohoff,Michael E. Greenberg,Anne Schaefer,Dorothy P. Schafer +16 more
TL;DR: It is shown that neurons communicate to microglia via activity-dependent fractalkine and ADAM10 signaling to induce removal of synapses in the brain after sensory loss, and that context-dependent immune mechanisms are utilized to remodel synapse elimination in the mammalian brain.