Ping Li

Bio: Ping Li is an academic researcher from China Medical University (PRC). The author has contributed to research in topics: Natriuretic peptide & Heart failure. The author has an hindex of 1, co-authored 2 publications receiving 4 citations.

Urine protein biomarkers for detection of cardiovascular disease and their use for the clinic.

Abstract: Cardiovascular disease (CVD) is the leading noncommunicable disease and main cause of death worldwide. Traditionally, blood has been the sample of choice for biomarker discovery, however, urine has roused great interest in recent years as a source of biomarkers. Sample collection is simple, non-invasive, and there is the possibility of implementing minimal cost tests in primary care settings. Areas covered: In this review, we systematically searched PubMed for proteomic studies of CVD, with the criteria that urine was included as a biological sample. Based on these criteria, and after manual curation, 47 research papers were included: 8 for coronary artery disease, 5 for angina, 15 for myocardial infarction, 23 for heart failure, and 4 for cerebrovascular disease. Expert commentary: Urinary biomarkers of early, asymptomatic stages of the disease would have a great impact on CVD morbidity and mortality, as widespread screening could be implemented at a reduced cost, allowing high-risk individuals to be identified and treated in a timely manner. An approach involving multiple biomarkers is necessary, as a single biomarker is unlikely to be sensitive/specific enough. By assessing a range of peptides there is the potential to detect changes in many pathways involved in the pathogenesis of CVDs.

Diuretic response and cardiorenal interaction in heart failure

Abstract: De nier speelt een sleutelrol bij patienten met hartfalen – de nieren en het hart zijn afhankelijk van elkaar om goed te kunnen functioneren. Dit proefschrift onderzoekt het belang van nierfunctie bij patienten met hartfalen, en manieren om deze te meten en beinvloeden. Een studie bevestigt het belang van nierfunctie voor het risico op overlijden in een meta-analyse bij meer dan 1 miljoen hartfalen patienten. Andere studies valideren recent ontwikkelde formules om nierfunctie te schatten en onderzoeken de potentiele rol die nieuwe biomarkers – stofjes die gemeten worden in bloed of urine – kunnen spelen om het belang van nierfunctiestoornissen bij patienten met hartfalen beter te begrijpen. De nier is ook een doelorgaan voor veel behandelingen voor hartfalen, waaronder diuretica – ‘plaspillen’ – medicijnen die helpen om de symptomen van overtollig vocht te verlichten. Resistentie tegen diuretica, waarbij deze medicijnen onvoldoende werken, is veel voorkomend, maar desondanks bestaat er geen eenduidige en bruikbare definitie. Wij hebben voor patienten met acuut hartfalen een maat ontwikkeld om de respons op diuretica te kwantificeren, om zo het fenomeen van resistentie beter te doorgronden. Slechte respons kwam vaker voor bij patienten met vergevorderd hartfalen, kransslagaderlijden, suikerziekte en nierfunctiestoornissen. Ook was slechte respons op diuretica geassocieerd met overlijden en ziekenhuisopnames, zelfs na correctie voor andere risicofactoren. Er zijn meerdere potentiele oorzaken voor slechte respons op diuretica, waaronder verminderde beschikbaarheid van het medicijn, en hormonale effecten op de nier. Beter begrip zal hopelijk leiden tot nieuwe behandelopties, en toekomstig onderzoek zal moeten uitwijzen welke het beste werken bij diuretica resistente patienten.

Blood cell parameters from early to middle pregnancy and risk of gestational diabetes mellitus.

Abstract: CONTEXT Chronic low-grade inflammation may play a crucial role in the pathogenesis of gestational diabetes mellitus (GDM). However, prospective studies on the relations of inflammatory blood cell parameters during pregnancy with GDM are lacking. OBJECTIVE To prospectively investigate the associations of inflammatory blood cell parameters in both early and middle pregnancy and their change patterns from early to middle pregnancy with GDM risk. METHODS We used data from the Tongji-Shuangliu Birth Cohort. Inflammatory blood cell parameters (white blood cells, neutrophils, lymphocytes, monocytes, neutrophil to lymphocyte ratio [NLR], and platelets) were assayed before 15 weeks and 16-28 gestational age. Logistic regression was used to evaluate the associations between inflammatory blood cell parameters and GDM. RESULTS Of the 6354 pregnant women, 445 were diagnosed with GDM. After adjustment for potential confounders, white blood cells, neutrophils, lymphocytes, monocytes, and NLR in early pregnancy were positively associated with GDM risk (odds ratios [OR] [95% CI] for extreme-quartile comparison were 2.38 [1.76-3.20], 2.47 [1.82-3.36], 1.40 [1.06-1.85], 1.69 [1.27-2.24], and 1.51 [1.12-2.02], respectively, all P for trend ≤.010). Higher level of white blood cells, neutrophils, monocytes, and NLR in middle pregnancy were associated with an increased risk of GDM (all P for trend ≤.014). Stable high levels (≥median in both early and middle pregnancy) of white blood cells, neutrophils, monocytes, and NLR were positively associated with GDM risk (all P ≤.001). CONCLUSION Elevated white blood cells, neutrophils, monocytes, and NLR in both early and middle pregnancy and their stable high levels from early to middle pregnancy were associated with a higher GDM risk, highlighting that they might be clinically relevant for identifying individuals at high risk for GDM.