Ping Lue

Bio: Ping Lue is an academic researcher from University of Florida. The author has contributed to research in topics: Benzotriazole & Sodium hydride. The author has an hindex of 13, co-authored 23 publications receiving 624 citations.

Amidines and guanidines in medicinal chemistry.

Abstract: Publisher Summary This chapter focuses on amidines and guanidines in medicinal chemistry. The drugs are classified under their main physiological activities and within each group are arranged roughly in order of increasing molecular complexity. Many of the compounds have given temporary excitement to their discoverers and then been dropped—the commonest experience in medicinal chemistry. There are important, clinically used, medicines in all the major categories of therapeutic action discussed in the chapter. This simple and very unstable compound is not only a neurotransmitter in the brain, but acts in the dilation of blood vessels and activates leucocytes to attack tumour cells, fungi, and bacteria. In addition, nitric oxide can inhibit blood coagulation by preventing platelet aggregation and appears to be the regulator of the male erection. No doubt other functions will be discovered in the future, but the interesting finding for the present chapter is that the NO is formed by nitric oxide synthetase from arginine—the only essential amino acid which carries a guanidine group. Since most of the active guanidine drugs have at least one unsubstituted =NH or NH 2 group, it is interesting to speculate that they will be shown to act by giving nitric oxide as well.

The chemistry of N-substituted benzotriazoles. Part 14. Novel routes to secondary and tertiary amines and to N, N-disubstituted hydroxylamines

Abstract: Tertiary amines of types R4R3CHNR1R2(2), (R2CH2)2NR1(10) and (11), or (R2CH2)3N (12), secondary amines of type (R2CH2)2NH (8), and N, N-disubstituted hydroxylamines of type (R2CH2)2NOH (9), are prepared in high yield by the action of Grignard reagents or sodium borohydride on easily available N, N-dialkyl-N-[benzotriazolylalkyl-(or arylalkyl-)]amines (1) or tris(benzotriazolylmethyl)amine (7), on bis(benzotriazolylmethyl)amines (3), (5), and (6), and on N, N-bis(benzotriazolylmethyl)hydroxylamine (4), respectively.

The chemistry of benzotriazole. 10. A conceptually new approach to the synthesis of secondary amides and thioamides

Abstract: Amides and thioamides of type RC(=X)NHCHR 1 R 2 are prepared in high yield with the formation of a new C-R 2 bond by the action of a Grignard reagent (R 2 MgX) on the readily available adducts from an amide RCONH 2 (or thioamide RCSNH 2 ), aldehyde R 1 CHO, and benzotriazole

An alternative route to 2-substituted indoles via N-aminal-directed lithiation

Abstract: La synthese d'alkyl-2 indole se fait par lithiation, en position 2, d'aminals d'indoles proteges en position 1, suivie d'une reaction electrophile et d'une elimination du substituant en position 1 par reduction par NaBH 4