P
Ping Zhai
Researcher at Northwestern University
Publications - 5
Citations - 4985
Ping Zhai is an academic researcher from Northwestern University. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Motor neuron. The author has an hindex of 4, co-authored 5 publications receiving 4757 citations.
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Journal ArticleDOI
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.
Mark E. Gurney,Haifeng Pu,Arlene Y. Chiu,Mauro C. Dal Canto,Cynthia Y. Polchow,Denise D. Alexander,Jan Caliendo,Afif Hentati,Young W. Kwon,Han Xiang Deng,W. Chen,Ping Zhai,Robert L. Sufit,Teepu Siddique +13 more
TL;DR: In this article, the authors found that mutations of human Cu,Zn superoxide dismutase (SOD) contribute to the pathogenesis of familial amyotrophic lateral sclerosis (ALS).
Journal ArticleDOI
Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis.
Mark E. Gurney,Frank B. Cutting,Ping Zhai,Adam Doble,Charles Taylor,Paula K. Andrus,Edward D. Hall +6 more
TL;DR: The hypothesis that oxidative damage produced by the expression of mutant Cu,Zn SOD causes slow or weak excitotoxicity that can be inhibited in part by altering glutamate release or biosynthesis presynaptically is suggested.
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Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Arlene Y. Chiu,Ping Zhai,Mauro C. Dal Canto,Theresa M. Peters,Young W. Kwon,Susan M. Prattis,Mark E. Gurney +6 more
TL;DR: The age-dependent penetrance of motor neuron disease in this transgenic model is due to the gradual accumulation of pathological damage in select populations of cholinergic neurons.
Journal ArticleDOI
Enhancer, silencer, and growth factor responsive regulatory sequences in the promoter for the mouse choline acetyltransferase gene.
TL;DR: Results indicate that regulation of the ChAT gene is achieved by a combination of both positive and negative regulatory mechanisms whose interaction determines the expression of a cholinergic neuronal phenotype.
babapenun in a Transgenic Model of ~dd AmyotropfUc Lateral sclerosis
Mark E. Gurney,Frank B. Cutting,Ping Zhai,Adam Doble,Charles Taylor,Paula K. Andrus,Edward D. Hall +6 more
TL;DR: The hypothesis that oxidative damage produced by the expression of mutant Cu,Zn SOD causes slow or weak excitotoxicity that can be inhibited in part by altering glutamate release or biosynthesis presynaptically is suggested.