P
Piotr Gałecki
Researcher at Medical University of Łódź
Publications - 245
Citations - 5101
Piotr Gałecki is an academic researcher from Medical University of Łódź. The author has contributed to research in topics: Single-nucleotide polymorphism & Medicine. The author has an hindex of 31, co-authored 219 publications receiving 3993 citations.
Papers
More filters
Journal ArticleDOI
A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness.
TL;DR: It is concluded that aberrations in O&NS pathways are--together with the inflammatory processes--key components of depression, and the results suggest that depression belongs to the spectrum of (neuro)degenerative disorders.
Journal ArticleDOI
The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression
TL;DR: It was shown that the patients' cells repaired peroxide-induced DNA damage less efficiently than controls' cells and that some single nucleotide polymorphisms of the genes involved in oxidative DNA damage repair may modulate the risk of depression.
Journal ArticleDOI
The glutathione system: a new drug target in neuroimmune disorders.
Gerwyn Morris,George M. Anderson,Olivia M Dean,Michael Berk,Michael Berk,Piotr Gałecki,Marta Martin-Subero,Michael Maes,Michael Maes +8 more
TL;DR: GSH depletion and concomitant increase in O&NS and mitochondrial dysfunctions play a role in the pathophysiology of diverse neuroimmune disorders, including depression, myalgic encephalomyelitis/chronic fatigue syndrome and Parkinson’s disease, suggesting that depleted GSH is an integral part of these diseases.
Journal ArticleDOI
The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder.
Piotr Gałecki,Elżbieta Gałecka,Michael Maes,Marcelina Chamielec,Agata Orzechowska,Kinga Bobińska,Andrzej Lewiński,Janusz Szemraj +7 more
TL;DR: The results indicate and may confirm the role of peripheral IO&NS pathways in the pathophysiology of depression and represent a promising way to investigate biological markers of depression.
Journal ArticleDOI
The anti-inflammatory mechanism of antidepressants – SSRIs, SNRIs
TL;DR: The aim of the work will be to perform a review of contemporary literature in order to present the latest scientific reports regarding the anti-inflammatory effects of SSRIs and SNRIs.