P
Piret Kleis
Researcher at University of Freiburg
Publications - 5
Citations - 28
Piret Kleis is an academic researcher from University of Freiburg. The author has contributed to research in topics: Hippocampal formation & Optogenetics. The author has an hindex of 1, co-authored 2 publications receiving 7 citations.
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Journal ArticleDOI
Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy.
Enya Paschen,Claudio Elgueta,Katharina Heining,Diego Mota Vieira,Piret Kleis,Catarina Orcinha,Ute Häussler,Marlene Bartos,Ulrich Egert,Philipp Janz,Carola A. Haas +10 more
TL;DR: In this paper, optogenetic and electrical low-frequency stimulation (LFS) was applied in the sclerotic hippocampus to study the effects on spontaneous subclinical and evoked generalized seizures.
Journal ArticleDOI
Long-term in vivo application of a potassium channel-based optogenetic silencer in the healthy and epileptic mouse hippocampus
TL;DR: In this article , the PACK tool has two components: a photoactivated adenylyl cyclase from Beggiatoa (bPAC) and a cAMP-dependent potassium channel, which carries a large, long-lasting potassium current in mammalian cells.
Journal ArticleDOI
Long-term in vivo application of a potassium channel-based optogenetic silencer in the healthy and epileptic mouse hippocampus
TL;DR: In this article , the PACK tool has two components: a photoactivated adenylyl cyclase from Beggiatoa (bPAC) and a cAMP-dependent potassium channel, which carries a large, long-lasting potassium current in mammalian cells.
Posted ContentDOI
In vivo characterization and application of a novel potassium channel-based optogenetic silencer in the healthy and epileptic mouse hippocampus
TL;DR: In this article, a photoactivated adenylyl cyclase (bPAC) and a cAMP-dependent potassium channel (SthK) were used to suppress pyramidal cells in healthy and epileptic adult male mice.
Posted ContentDOI
On-demand low-frequency stimulation for seizure control: efficacy and behavioral implications
Enya Paschen,Piret Kleis,Diego Mota Vieira,Katharina Heining,Christian Boehler,Ulrich Egert,Ute Häussler,Carola A. Haas +7 more
TL;DR: In this article , an online detection algorithm monitored epileptiform activity in hippocampal local field potential recordings and identified short seizureiform bursts preceding focal seizure clusters, triggering hippocampal LFS to stabilize the network state.