P
Polymnia Georgiou
Researcher at University of Maryland, Baltimore
Publications - 40
Citations - 2995
Polymnia Georgiou is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Oxytocin receptor & Nucleus accumbens. The author has an hindex of 20, co-authored 36 publications receiving 2154 citations. Previous affiliations of Polymnia Georgiou include University of Surrey.
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Journal ArticleDOI
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Panos Zanos,Ruin Moaddel,Patrick J. Morris,Polymnia Georgiou,Jonathan Fischell,Greg I. Elmer,Manickavasagom Alkondon,Peixiong Yuan,Heather J. Pribut,Nagendra Singh,Katina Sourou Sylvestre Dossou,Yuhong Fang,Xi Ping Huang,Cheryl L. Mayo,Irving W. Wainer,Edson X. Albuquerque,Scott M. Thompson,Craig J. Thomas,Carlos A. Zarate,Todd D. Gould +19 more
TL;DR: It is shown that the metabolism of (R,S)-ketamine to (2S,6S;2R,6R)-hydroxynorketamine (HNK) is essential for its antidepressant effects, and that the HNK enantiomer exerts behavioural, electroencephalographic, electrophysiological and cellular antidepressant-related actions in mice.
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Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms
Panos Zanos,Ruin Moaddel,Patrick J. Morris,Lace M. Riggs,Jaclyn N. Highland,Polymnia Georgiou,Edna F. R. Pereira,Edson X. Albuquerque,Craig J. Thomas,Carlos A. Zarate,Todd D. Gould +10 more
TL;DR: Pharmacological target deconvolution of ketamine and its metabolites will provide insight critical to the development of new pharmacotherapies that possess the desirable clinical effects of ketamines, but limit undesirable side effects.
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The Oxytocin Analogue Carbetocin Prevents Emotional Impairment and Stress-Induced Reinstatement of Opioid-Seeking in Morphine-Abstinent Mice
Panos Zanos,Polymnia Georgiou,Wright,Susanna M.O. Hourani,Ian Kitchen,Raphaelle Winsky-Sommerer,Alexis Bailey +6 more
TL;DR: In this paper, the effect of 7-day opioid abstinence on the oxytocinergic system was investigated and the effects of carbetocin (CBT) on the emotional consequences of opioid abstinence, as well as relapse.
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(2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions.
Panos Zanos,Jaclyn N. Highland,Brent W. Stewart,Polymnia Georgiou,Carleigh Jenne,Jacqueline Lovett,Patrick J. Morris,Craig J. Thomas,Ruin Moaddel,Carlos A. Zarate,Todd D. Gould,Todd D. Gould +11 more
TL;DR: The findings highlight that (2R,6R)-HNK exerts antidepressant-relevant actions via a mechanism converging with mGlu2 receptor signaling and suggest enhanced cortical gamma oscillations as a marker of target engagement relevant to antidepressant efficacy.
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Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula-Tegmental Circuitry and Constrain Reward Seeking.
Jessica R. Tooley,Lauren J. Marconi,Jason B. Alipio,Bridget A. Matikainen-Ankney,Polymnia Georgiou,Alexxai V. Kravitz,Meaghan C. Creed +6 more
TL;DR: A noncanonical population of glutamatergic VP neurons are identified that play a unique role in responding to aversive stimuli and constraining inappropriate reward seeking.