Author
Ponisseril Somasundaran
Other affiliations: Stony Brook University, Purdue University, Hebrew University of Jerusalem ...read more
Bio: Ponisseril Somasundaran is an academic researcher from Columbia University. The author has contributed to research in topics: Adsorption & Pulmonary surfactant. The author has an hindex of 65, co-authored 504 publications receiving 24852 citations. Previous affiliations of Ponisseril Somasundaran include Stony Brook University & Purdue University.
Papers published on a yearly basis
Papers
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TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
Abstract: Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.
6,075 citations
Book•
15 Jun 2006TL;DR: This comprehensive reference collects fundamental theories and recent research from a wide range of fields including biology, biochemistry, physics, applied mathematics, and computer, materials, surface, and colloid science providing key references, tools, and analytical techniques for practical applications in industrial, agricultural, and forensic processes.
Abstract: This comprehensive reference collects fundamental theories and recent research from a wide range of fields including biology, biochemistry, physics, applied mathematics, and computer, materials, surface, and colloid science-providing key references, tools, and analytical techniques for practical applications in industrial, agricultural, and forensic processes, as well as in the production of natural and synthetic compounds such as foods, minerals, paints, proteins, pharmaceuticals, polymers, and soaps.
1,829 citations
TL;DR: An attempt is made to derive structure-property relationships to provide a solid foundation for the design and use of surfactant formulations for industrial applications.
648 citations
TL;DR: The homopolar dipole vanishes in the case of --4 D./A.C>r)re of --3 D/A.B because of the overlap integral.
Abstract: C>r)re of --4 D./A. However, care should be taken sincewe initially assumed that 'P' A. a.nd 'P'B are orthogonal a.nd in this case the homopolar dipole vanishes. If we had included the overlap integral, then the primary moments would have changed somewhat. Ackr&OtDl«IgmentB. We wish to thank Proiessor Harrison Shull for his interest and hospitality. Our tha.nks a.re &Iso due to Mr. John P. Chandler and ~Ir. Robert Fern for their help with computational pro\>lems.
567 citations
TL;DR: The zero point of charge (ZPC) of calcite was investigated by measuring the streaming potential, solution equilibrium, and flotation response as a function of solution pH.
454 citations
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TL;DR: A new method, based on chemical thermodynamics, is developed for automatic detection of macromolecular assemblies in the Protein Data Bank (PDB) entries that are the results of X-ray diffraction experiments, as found, biological units may be recovered at 80-90% success rate, which makesX-ray crystallography an important source of experimental data on macromolescular complexes and protein-protein interactions.
8,377 citations
TL;DR: By successively addressing each of the biological barriers that a particle encounters upon intravenous administration, innovative design features can be rationally incorporated that will create a new generation of nanotherapeutics, realizing a paradigmatic shift in nanoparticle-based drug delivery.
Abstract: Biological barriers to drug transport prevent successful accumulation of nanotherapeutics specifically at diseased sites, limiting efficacious responses in disease processes ranging from cancer to inflammation. Although substantial research efforts have aimed to incorporate multiple functionalities and moieties within the overall nanoparticle design, many of these strategies fail to adequately address these barriers. Obstacles, such as nonspecific distribution and inadequate accumulation of therapeutics, remain formidable challenges to drug developers. A reimagining of conventional nanoparticles is needed to successfully negotiate these impediments to drug delivery. Site-specific delivery of therapeutics will remain a distant reality unless nanocarrier design takes into account the majority, if not all, of the biological barriers that a particle encounters upon intravenous administration. By successively addressing each of these barriers, innovative design features can be rationally incorporated that will create a new generation of nanotherapeutics, realizing a paradigmatic shift in nanoparticle-based drug delivery.
4,457 citations
TL;DR: In this paper, photo-induced superhydrophilicity was used on the surface of a wide-band gap semiconductor like titanium dioxide (TiO 2 ) for photocatalytic activity towards environmentally hazardous compounds.
4,241 citations
TL;DR: In this paper, the influence of alloy chemistry, thermomechanical processing and surface condition on these properties is discussed and various surface modification techniques to achieve superior biocompatibility, higher wear and corrosion resistance.
4,113 citations
TL;DR: Novel engineering approaches are discussed that capitalize on the growing understanding of tumour biology and nano–bio interactions to develop more effective nanotherapeutics for cancer patients.
Abstract: The intrinsic limits of conventional cancer therapies prompted the development and application of various nanotechnologies for more effective and safer cancer treatment, herein referred to as cancer nanomedicine. Considerable technological success has been achieved in this field, but the main obstacles to nanomedicine becoming a new paradigm in cancer therapy stem from the complexities and heterogeneity of tumour biology, an incomplete understanding of nano-bio interactions and the challenges regarding chemistry, manufacturing and controls required for clinical translation and commercialization. This Review highlights the progress, challenges and opportunities in cancer nanomedicine and discusses novel engineering approaches that capitalize on our growing understanding of tumour biology and nano-bio interactions to develop more effective nanotherapeutics for cancer patients.
3,800 citations