Author
Ponneri Chandrababu Ravikumar
Other affiliations: Indian Institute of Technology Mandi, Yale University, University of Tübingen ...read more
Bio: Ponneri Chandrababu Ravikumar is an academic researcher from National Institute of Science Education and Research. The author has contributed to research in topics: Catalysis & Chemistry. The author has an hindex of 12, co-authored 55 publications receiving 1348 citations. Previous affiliations of Ponneri Chandrababu Ravikumar include Indian Institute of Technology Mandi & Yale University.
Topics: Catalysis, Chemistry, Medicine, Total synthesis, Maleimide
Papers published on a yearly basis
Papers
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TL;DR: This research presents a novel, scalable, and scalable approaches that can be applied to the rapidly changing and rapidly changing environment of drug discovery and development.
Abstract: Fraser F. Fleming,* Lihua Yao, P. C. Ravikumar, Lee Funk, and Brian C. Shook Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282-1530, Mylan Pharmaceuticals Inc., 781 Chestnut Ridge Road, Morgantown, West Virginia 26505, and Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Welsh and McKean Roads, P.O. Box 776, Spring House, Pennsylvania 19477
1,058 citations
TL;DR: In this article, a nanocomposite comprising of MoS2-RGO having unique structural features was developed by using a facile preparation strategy and demonstrated to be a highly efficient heterogeneous catalyst for the synthesis of indole alkaloids in water.
Abstract: A nanocomposite comprising of MoS2-RGO having unique structural features was developed by using a facile preparation strategy and demonstrated to be a highly efficient heterogeneous catalyst for the synthesis of indole alkaloids in water. The catalyst could be recycled six times without significant loss of its activity. Green chemistry matrices calculations for the reaction showed high atom economy (A.E. = 94.7%) and small E-factor (0.089). Using this nanocomposite as catalyst, four naturally occurring indole alkaloid, namely Arundine, Vibrindole A, Turbomycin B and Trisindole, were synthesized along with their other derivatives in excellent yields.
61 citations
TL;DR: A conceptually new dimethyl sulfoxide (DMSO) based oxidation process without the use of any activator has been demonstrated for the oxidation of active methylenes and benzhydrols.
49 citations
TL;DR: The first report on the selective C(4)-H functionalization of 3-acetylindole derivatives using first-row transition metal cobalt where an acetyl group is acting as a weakly coordinating directing group is disclosed.
48 citations
TL;DR: Hydarylation of unprotected maleimide using indolines was a challenging substrate and never accomplished before, but the method was able to achieve this with the methodology in good yields.
37 citations
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Book•
01 Jan 1979
5,044 citations
469 citations
TL;DR: Allenes have proven themselves to be valuable building blocks toward complex molecular targets, revealing novel applications in natural product synthesis, pharmaceutical chemistry and materials science, and some of the recent important developments on the synthesis of allenes are highlighted.
420 citations
TL;DR: This review aims to cover the developments of the past decade in the chemistry of organic sulfur(IV) molecules and provide insight into both the wide range of reactions which critically rely on this versatile element and the diverse scaffolds that can thereby be synthesized.
Abstract: Organosulfur compounds have long played a vital role in organic chemistry and in the development of novel chemical structures and architectures. Prominent among these organosulfur compounds are those involving a sulfur(IV) center, which have been the subject of countless investigations over more than a hundred years. In addition to a long list of textbook sulfur-based reactions, there has been a sustained interest in the chemistry of organosulfur(IV) compounds in recent years. Of particular interest within organosulfur chemistry is the ease with which the synthetic chemist can effect a wide range of transformations through either bond formation or bond cleavage at sulfur. This review aims to cover the developments of the past decade in the chemistry of organic sulfur(IV) molecules and provide insight into both the wide range of reactions which critically rely on this versatile element and the diverse scaffolds that can thereby be synthesized.
419 citations
TL;DR: A copper-catalyzed radical relay pathway for enantioselective conversion of benzylic C–H bonds intobenzylic nitriles is reported, providing evidence for diffusible organic radicals and highlighting the difference between these reactions and C-H oxidations mediated by enzymes and other catalysts that operate via radical rebound pathways.
Abstract: Direct methods for stereoselective functionalization of sp3-hybridized carbon–hydrogen [C(sp3)–H] bonds in complex organic molecules could facilitate much more efficient preparation of therapeutics and agrochemicals. Here, we report a copper-catalyzed radical relay pathway for enantioselective conversion of benzylic C–H bonds into benzylic nitriles. Hydrogen-atom abstraction affords an achiral benzylic radical that undergoes asymmetric C(sp3)–CN bond formation upon reaction with a chiral copper catalyst. The reactions proceed efficiently at room temperature with the benzylic substrate as limiting reagent, exhibit broad substrate scope with high enantioselectivity (typically 90 to 99% enantiomeric excess), and afford products that are key precursors to important bioactive molecules. Mechanistic studies provide evidence for diffusible organic radicals and highlight the difference between these reactions and C–H oxidations mediated by enzymes and other catalysts that operate via radical rebound pathways.
416 citations