P
Pornpimol Charoentong
Researcher at German Cancer Research Center
Publications - 47
Citations - 11685
Pornpimol Charoentong is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Immune system & Cancer. The author has an hindex of 23, co-authored 43 publications receiving 7105 citations. Previous affiliations of Pornpimol Charoentong include Heidelberg University & Pierre-and-Marie-Curie University.
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Journal ArticleDOI
ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks
Gabriela-Luana Bindea,Bernhard Mlecnik,Hubert Hackl,Pornpimol Charoentong,Marie Tosolini,Amos Kirilovsky,Wolf H. Fridman,Franck Pagès,Zlatko Trajanoski,Jérôme Galon +9 more
TL;DR: ClueGO is an easy to use Cytoscape plug-in that strongly improves biological interpretation of large lists of genes and creates a functionally organized GO/pathway term network.
Journal ArticleDOI
Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade
Pornpimol Charoentong,Francesca Finotello,Mihaela Angelova,Clemens Mayer,Mirjana Efremova,Dietmar Rieder,Hubert Hackl,Zlatko Trajanoski +7 more
TL;DR: The immunophenoscore was a superior predictor of response to anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) and anti-programmed cell death protein 1 (anti-PD-1) antibodies in two independent validation cohorts and may help inform cancer immunotherapy and facilitate the development of precision immuno-oncology.
Posted ContentDOI
Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade
Pornpimol Charoentong,Francesca Finotello,Mihaela Angelova,Clemens Mayer,Mirjana Efremova,Dietmar Rieder,Hubert Hackl,Zlatko Trajanoski +7 more
TL;DR: Cellular characterization of the immune infiltrates revealed a role of cancer-germline antigens in spontaneous immunity and showed that tumor genotypes determine immunophenotypes and tumor escape mechanisms and a scoring scheme for the quantification termed immunophenoscore was developed.
Journal ArticleDOI
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data
Francesca Finotello,Clemens Mayer,Christina Plattner,Gerhard Laschober,Dietmar Rieder,Hubert Hackl,Anne Krogsdam,Zuzana Loncova,Wilfried Posch,Doris Wilflingseder,Sieghart Sopper,Marieke E. Ijsselsteijn,Thomas P. Brouwer,Douglas B. Johnson,Douglas B. Johnson,Yaomin Xu,Yu Wang,Melinda E. Sanders,Monica V. Estrada,Paula Ericsson-Gonzalez,Pornpimol Charoentong,Pornpimol Charoentong,Justin M. Balko,Justin M. Balko,Noel F C C de Miranda,Zlatko Trajanoski +25 more
TL;DR: QuanTIseq as discussed by the authors is a method to quantify the fractions of ten immune cell types from bulk RNA-sequencing data, which is extensively validated in blood and tumor samples using simulated, flow cytometry, and immunohistochemistry data.
Journal ArticleDOI
Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study.
Jakob Nikolas Kather,Johannes Krisam,Pornpimol Charoentong,Pornpimol Charoentong,Tom Luedde,Esther Herpel,Cleo Aron Weis,Timo Gaiser,Alexander Marx,Nektarios A. Valous,Nektarios A. Valous,Dyke Ferber,Dyke Ferber,Lina Jansen,Constantino Carlos Reyes-Aldasoro,Inka Zörnig,Inka Zörnig,Dirk Jäger,Dirk Jäger,Hermann Brenner,Jenny Chang-Claude,Michael Hoffmeister,Niels Halama +22 more
TL;DR: It is shown that a CNN can assess the human tumor microenvironment and predict prognosis directly from histopathological images and was an independent prognostic factor for overall survival in a multivariable Cox proportional hazard model.