P
Portia M. Gillespie
Researcher at Baylor College of Medicine
Publications - 26
Citations - 976
Portia M. Gillespie is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Pichia pastoris & Immunogenicity. The author has an hindex of 14, co-authored 24 publications receiving 744 citations. Previous affiliations of Portia M. Gillespie include George Washington University & Boston Children's Hospital.
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Journal ArticleDOI
Status of vaccine research and development of vaccines for leishmaniasis.
Portia M. Gillespie,Coreen M. Beaumier,Coreen M. Beaumier,Ulrich Strych,Ulrich Strych,Tara Hayward,Peter J. Hotez,Maria Elena Bottazzi +7 more
TL;DR: Leishmaniasis is a vector-borne neglected tropical disease caused by a protozoan parasite of the genus Leishmania and transmitted to humans by the bite of a sand fly, and both VL and CL vaccines have been shown to be cost-effective in economic modeling studies.
Journal ArticleDOI
New vaccines for neglected parasitic diseases and dengue.
TL;DR: The progress on dengue, hookworm, leishmaniasis, schistosomiasis, Chagas disease, and onchocerciasis vaccines are reported, some of the first with specific objectives to aid the world's poorest populations.
Journal ArticleDOI
Advancing a vaccine to prevent human schistosomiasis
Maureen Merrifield,Peter J. Hotez,Coreen M. Beaumier,Portia M. Gillespie,Portia M. Gillespie,Ulrich Strych,Ulrich Strych,Tara Hayward,Maria Elena Bottazzi +8 more
TL;DR: The target product profiles of these vaccines vary but many focus on vaccinating children, in some cases following mass treatment with praziquantel, also known as vaccine-linked chemotherapy.
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Molecular Cloning, Biochemical Characterization, and Partial Protective Immunity of the Heme-Binding Glutathione S-Transferases from the Human Hookworm Necator americanus
Bin Zhan,Samirah Perally,Peter M. Brophy,Jian Xue,Gaddam Goud,Sen Liu,Vehid Deumic,Luciana M. Oliveira,Jeffrey M. Bethony,Maria Elena Bottazzi,Desheng Jiang,Portia M. Gillespie,Shu-Hua Xiao,Richi Gupta,Alex Loukas,Najju Ranjit,Sara Lustigman,Yelena Oksov,Peter J. Hotez +18 more
TL;DR: Three cDNAs isolated from the human hookworm Necator americanus encoding a full-length GST protein belonging to a nematode-specific nu-class GST family exhibited low lipid peroxidase and glutathione-conjugating enzyme activities but high heme-binding capacities, and they may be involved in the detoxification and/or transport of heme.
Journal ArticleDOI
Status of vaccine research and development of vaccines for Chagas disease.
Coreen M. Beaumier,Portia M. Gillespie,Ulrich Strych,Tara Hayward,Peter J. Hotez,Maria Elena Bottazzi +5 more
TL;DR: This poster presents a probabilistic procedure called a “shots fired” procedure called “spiking the motility of the immune cells” to induce an immune response to vaccine-preventable diseases.